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Molecular evidence predicts aryl hydrocarbon receptor ligand insensitivity in the peregrine falcon (Falco peregrines)

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Title: Molecular evidence predicts aryl hydrocarbon receptor ligand insensitivity in the peregrine falcon (Falco peregrines)
Authors: Fujisawa, Nozomi Browse this author
Ikenaka, Yoshinori Browse this author →KAKEN DB
Kim, Eun-Young Browse this author
Lee, Jin-Seon Browse this author
Iwata, Hisato Browse this author
Ishizuka, Mayumi Browse this author →KAKEN DB
Keywords: Avian
Dioxin
Raptor
Falcon
Aryl hydrocarbon receptor
Issue Date: Feb-2012
Publisher: Springer-Verlag
Journal Title: European Journal of Wildlife Research
Volume: 58
Issue: 1
Start Page: 167
End Page: 175
Publisher DOI: 10.1007/s10344-011-0559-1
Abstract: Some wild populations of fish-eating birds and raptors are exposed to high concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds such as other 2,3,7,8-substituted polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans and coplanar polychlorinated biphenyls, resulting in accumulation in their tissues. It has been demonstrated that TCDD-like chemicals cause toxic effects via aryl hydrocarbon receptor (AHR)-mediated signaling pathways. The aim of this study was to characterize the AHR from the peregrine falcon (Falco peregrines) to predict its sensitivity to TCDD-like chemicals. The AHR1, AHR2, and AHR nuclear translocator (ARNT) 1 of the peregrine falcon are more similar in amino acid sequence to avian species less sensitive to TCDD-like chemicals such as the cormorant (95%) than to more sensitive species such as the chicken (90%). From the amino acid sequence, it is likely that the ligand-binding affinity of peregrine falcon AHR1 and AHR2 would be very low compared with the chicken or other sensitive species, and it was actually proved by an in vitro reporter gene assay. We concluded that the peregrine falcon, one of raptor species, may be relatively resistant to TCDD-like chemicals.
Rights: The original publication is available at www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/51759
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石塚 真由美

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