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Involvement of apoptosis and proliferation of acinar cells in atrophy of rat parotid glands induced by liquid diet

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Title: Involvement of apoptosis and proliferation of acinar cells in atrophy of rat parotid glands induced by liquid diet
Authors: Takahashi, Shigeru Browse this author →KAKEN DB
Uekita, Hiroki Browse this author
Kato, Tsuyoshi Browse this author
Yuge, Fumihiko Browse this author
Ushijima, Natsumi Browse this author
Inoue, Kiichiro Browse this author →KAKEN DB
Domon, Takanori Browse this author →KAKEN DB
Keywords: Liquid diet
Cell proliferation
Parotid gland
Issue Date: Dec-2012
Publisher: Springer Netherlands
Journal Title: Journal of Molecular Histology
Volume: 43
Issue: 6
Start Page: 761
End Page: 766
Publisher DOI: 10.1007/s10735-012-9442-y
PMID: 22918835
Abstract: Parotid glands of experimental animals fed a liquid diet are reported to show atrophy (Hall and Schneyer 1964; Wilborn and Schneyer 1970; Hand and Ho 1981; Scott et al. 1990; Scott and Gunn 1991). To clarify whether apoptosis and proliferation of acinar cells participate in atrophy of rat parotid glands induced by liquid diet, rats were fed a liquid diet and compared to pellet-fed controls. Parotid glands were removed at 3, 7, 14 or 21 days, weighed, and examined using transmission electron microscopy (TEM), and studied immunohistochemically for cleaved-caspase-3 (Casp-3), a marker of apoptotic cells, and 5-bromo-2'-deoxyuridine (BrdU), a marker for proliferating cells. Body weights of experimental rats fed liquid diets were not significantly different from controls fed pellet diets; however weights of experimental parotid glands were smaller than those of controls. In the experimental parotid glands, structures like apoptotic bodies were histologically observed in acini at each time point; more Casp-3-positive acinar cells were identified in experimental parotid glands than in the controls on days 3, 7, and 14. Experimental glands showed fewer BrdU-positive acinar cells at each time point. TEM confirmed typical apoptotic acinar cells in the atrophic glands. These findings suggest that increased acinar cell apoptosis and reduced acinar cell proliferation occur in atrophic parotid glands of rats fed a liquid diet.
Rights: The final publication is available at
Type: article (author version)
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高橋 茂

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