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Comparison of Gastric Relaxation and Sensory Functions between Functional Dyspepsia and Healthy Subjects Using Novel Drinking-Ultrasonography Test

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Title: Comparison of Gastric Relaxation and Sensory Functions between Functional Dyspepsia and Healthy Subjects Using Novel Drinking-Ultrasonography Test
Authors: Hata, Tamotsu Browse this author
Kato, Mototsugu Browse this author →KAKEN DB
Kudo, Takahiko Browse this author
Nishida, Mutsumi Browse this author
Nishida, Urara Browse this author
Imai, Aki Browse this author
Yoshida, Takeshi Browse this author
Hirota, Jyojyo Browse this author
Kamada, Go Browse this author
Ono, Shouko Browse this author
Nakagawa, Manabu Browse this author
Nakagawa, Soichi Browse this author
Shimizu, Yuichi Browse this author →KAKEN DB
Takeda, Hiroshi Browse this author
Asaka, Masahiro Browse this author →KAKEN DB
Keywords: Functional gastroduodenal disorders
Drink test
Ultrasonography
Gastric accommodation
Gastric emptying
Visceral hypersensitivity
Issue Date: Jan-2013
Publisher: Karger
Journal Title: Digestion
Volume: 87
Issue: 1
Start Page: 34
End Page: 39
Publisher DOI: 10.1159/000343935
PMID: 23343967
Abstract: Background: Functional dyspepsia (FD) is a heterogeneous disease characterized by various upper abdominal symptoms. The major mechanism of FD includes impaired fundic accommodation, delayed gastric emptying, and visceral hypersensitivity. We developed a novel drinking-ultrasonography test to combine a drink test with ultrasonography to assess gastric motility and sensory function of FD patients. Method: Subjects were 20 healthy volunteers and 26 successive FD patients according to the Rome III criteria. The subjects ingested 200 ml of water at 2-min intervals 4 times (total 800 ml) through a straw. The maximum cross section of the proximal stomach was visualized before water intake, after each water intake, and 5 and 10 min after the completion of drinking using extracorporeal ultrasonography. Abdominal symptoms were evaluated using the visual analog scale (VAS) a total of 5 times. Results: The mean cross-sectional area of the fornix after 800-ml water intake was significantly lower in the FD group compared with the control group. In the FD group, marked abdominal symptoms developed immediately after initiation of water intake and VAS Score differed significantly (p < 0.01) between the control and FD groups at each time point. Conclusion: We developed the drinking-ultrasonography test and this novel test revealed abnormalities in gastric accommodation and sensation in patients with FD compared with healthy controls. This approach can be readily performed and allows the simultaneous evaluation of gastric accommodation, emptying and sensation.
Rights: © 2013 S. Karger AG, Basel
Type: article (author version)
URI: http://hdl.handle.net/2115/52030
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 元嗣

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