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11C-Methionine positron emission tomography may monitor the activity of encephalitis

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Title: 11C-Methionine positron emission tomography may monitor the activity of encephalitis
Authors: Hirata, Kenji Browse this author →KAKEN DB
Shiga, Tohru Browse this author →KAKEN DB
Fujima, Noriyuki Browse this author
Manabe, Osamu Browse this author
Usui, Reiko Browse this author
Kuge, Yuji Browse this author →KAKEN DB
Tamaki, Nagara Browse this author →KAKEN DB
Keywords: Encephalitis
positron emission tomography
therapy monitoring
Issue Date: Dec-2012
Publisher: Royal Society of Medicine Press
Journal Title: Acta Radiologica
Volume: 53
Issue: 10
Start Page: 1155
End Page: 1157
Publisher DOI: 10.1258/ar.2012.120382
PMID: 22993272
Abstract: Encephalitis is generally diagnosed by clinical symptoms, cerebrospinal fluid examination, and imaging studies including CT, MR imaging and perfusion single photon emission tomography (SPECT). However, the role of positron emission tomography (PET) in diagnosis of encephalitis remains unclear. A 49-year-old woman presenting with coma and elevated inflammatory reaction was diagnosed as having encephalitis according to slow activity on electroencephalogram, broad cortical lesion in MR fluid attenuated inversion recovery image, and increased blood flow demonstrated by SPECT. PET revealed increased accumulation of 11C-methionine (MET) in the affected brain tissues. After the symptom had improved two months later, the accumulation of MET as well as the abnormal findings of MR imaging and SPECT was normalized. This case indicated that MET PET may monitor the activity of encephalitis.
Rights: Acta Radiol, December 2012, 53(10), pp.1155-1157, doi: 10.1258/ar.2012.120382. This is the final draft, after peer-review, of a manuscript published in Acta Radiologica. The definitive version, detailed above, is available online at
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 平田 健司

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