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Reintroduction of H5N1 highly pathogenic avian influenza virus by migratory water birds, causing poultry outbreaks in the 2010-2011 winter season in Japan

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Title: Reintroduction of H5N1 highly pathogenic avian influenza virus by migratory water birds, causing poultry outbreaks in the 2010-2011 winter season in Japan
Authors: Sakoda, Yoshihiro Browse this author →KAKEN DB
Ito, Hiroshi Browse this author
Uchida, Yuko Browse this author
Okamatsu, Masatoshi Browse this author →KAKEN DB
Yamamoto, Naoki Browse this author
Soda, Kosuke Browse this author
Nomura, Naoki Browse this author
Kuribayashi, Saya Browse this author
Shichinohe, Shintaro Browse this author
Sunden, Yuji Browse this author →KAKEN DB
Umemura, Takashi Browse this author →KAKEN DB
Usui, Tatsufumi Browse this author
Ozaki, Hiroichi Browse this author
Yamaguchi, Tsuyoshi Browse this author
Murase, Toshiyuki Browse this author
Ito, Toshihiro Browse this author
Saito, Takehiko Browse this author
Takada, Ayato Browse this author →KAKEN DB
Kida, Hiroshi Browse this author →KAKEN DB
Keywords: avian influenza
migratory water birds
Issue Date: Mar-2012
Publisher: Society for General Microbiology
Journal Title: Journal of General Virology
Volume: 93
Issue: 3
Start Page: 541
End Page: 550
Publisher DOI: 10.1099/vir.0.037572-0
PMID: 22113008
Abstract: H5N1 highly pathogenic avian influenza virus (HPAIV) was reintroduced and caused outbreaks in chickens in 2010-2011 winter season in Japan, which had been free from highly pathogenic avian influenza (HPAI) since 2007 when HPAI outbreaks occurred and were controlled. On October 14, 2010 at Lake Ohnuma, Wakkanai, the northernmost part of Hokkaido, Japan, H5N1 HPAIVs were isolated from fecal samples of ducks flying from their nesting lakes in Siberia. Since then, in Japan, H5N1 HPAIVs have been isolated from 63 wild birds in 17 prefectures and caused HPAI outbreaks in 24 chicken farms in 9 prefectures by the end of March in 2011. Each of these isolates was genetically closely related to the HPAIV isolates at Lake Ohnuma, and those in China, Mongolia, Russia, and Korea, belonging to genetic clade In addition, these isolates were genetically classified into 3 groups, suggesting that the viruses were transmitted by migratory water birds through at least 3 different routes from their northern territory to Japan. These isolates were antigenic variants, which is consistent with selection in poultry under the immunological pressure induced by vaccination. To prevent the perpetuation of viruses in the lakes where water birds nest in summer in Siberia, prompt eradication of HPAIVs in poultry is urgently needed in Asian countries where HPAI has not been controlled.
Rights: This is an author manuscript that has been accepted for publication in Journal of General Virology, copyright Society for General Microbiology, but has not been copy-edited, formatted or proofed. J Gen Virol March 2012 vol. 93 no. 3 541-550. This version of the manuscript may not be duplicated or reproduced, other than for personal use or within the rule of 'Fair Use of Copyrighted Materials' (section 17, Title 17, US Code), without permission from the copyright owner, Society for General Microbiology. The Society for General Microbiology disclaims any responsibility or liability for errors or omissions in this version of the manuscript or in any version derived from it by any other parties. The final copy-edited, published article, which is the version of record, can be found at, and is freely available without a subscription 12 months after publication.
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 迫田 義博

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