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A novel mechanism for the promotion of quercetin glycoside absorption by megalo α-1,6-glucosaccharide in the rat small intestine

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Title: A novel mechanism for the promotion of quercetin glycoside absorption by megalo α-1,6-glucosaccharide in the rat small intestine
Authors: Shinoki, Aki Browse this author
Lang, Weeranuch Browse this author
Thawornkuno, Charin Browse this author
Kang, Hee-Kwon Browse this author
Kumagai, Yuya Browse this author
Okuyama, Masayuki Browse this author →KAKEN DB
Mori, Haruhide Browse this author →KAKEN DB
Kimura, Atsuo Browse this author →KAKEN DB
Ishizuka, Satoshi Browse this author →KAKEN DB
Hara, Hiroshi Browse this author →KAKEN DB
Keywords: α-1,6-Glucosaccharide
Quercetin glycoside
Absorption
Rats
Issue Date: 15-Jan-2013
Publisher: Elsevier
Journal Title: Food Chemistry
Volume: 136
Issue: 2
Start Page: 293
End Page: 296
Publisher DOI: 10.1016/j.foodchem.2012.08.028
PMID: 23122060
Abstract: The presence of α-1,6-glucosaccharide enhances absorption of water-soluble quercetin glycosides, a mixture of quercetin-3-O-β-D-glucoside (Q3G, 31.8%), mono (23.3%), di (20.3%) and more D-glucose adducts with α-1,4-linkage to D-glucose moiety of Q3G, in a ligated small intestinal loop of anesthetized rats. We enzymatically prepared α-1,6-glucosaccharides with different degrees of polymerization (DP) and separated them into a megaloisomaltosaccharide-containing fraction (M-IM, average DP = 11.0) and an oligoisomaltosaccharide-containing fraction (O-IM, average DP = 3.6). Luminal injection of either saccharide fractions promoted the absorption of total quercetin-derivatives from the small intestinal segment and this effect was greater for M-IM than O-IM addition. M-IM also increased Q3G, but not the quercetin aglycone, concentration in the water-phase of the luminal contents more strongly than O-IM. The enhancement of Q3G solubilization in the luminal contents may be responsible for the increases in the quercetin glucoside absorption promoted by α-1,6-glucosaccharides, especially M-IM. These results suggest that the ingestion of α-1,6-glucosaccharides promotes Q3G bioavailability.
Type: article (author version)
URI: http://hdl.handle.net/2115/52124
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 篠木 亜季

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