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Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds

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Title: Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds
Authors: Kato, Eisuke Browse this author →KAKEN DB
Kawabata, Jun Browse this author →KAKEN DB
Keywords: Puerarin
Isoflavone
Diabetes mellitus
PPARγ
Glucose uptake
Issue Date: 1-Aug-2010
Publisher: Elsevier
Journal Title: Bioorganic & Medicinal Chemistry Letters
Volume: 20
Issue: 15
Start Page: 4333
End Page: 4336
Publisher DOI: 10.1016/j.bmcl.2010.06.077
PMID: 20605096
Abstract: Chemical treatment of diabetes mellitus is widely studied and controlling of blood glucose level is the main course of therapy. In type 2 diabetes mellitus, insulin resistance is the major problem. An isoflavone C-glucoside, puerarin (1), is known to enhance glucose uptake into the insulin sensitive cell and is thought to be a candidate for treatment of diabetes mellitus. We synthesized 1 and several derivatives to apply for the structure-activity relationship study. The result against 3T3-L1 adipocyte indicated that the C-glucoside part of 1 is unconcerned in its activity when tested in vitro and the main structure responsible for its activity was the isoflavone moiety.
Type: article (author version)
URI: http://hdl.handle.net/2115/52134
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 英介

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