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Hokkaido University Collection of Scholarly and Academic Papers >
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Peer-reviewed Journal Articles, etc >
Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds
| Title: | Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds |
| Authors: | Kato, Eisuke Browse this author →KAKEN DB | | Kawabata, Jun Browse this author →KAKEN DB |
| Keywords: | Puerarin | | Isoflavone | | Diabetes mellitus | | PPARγ | | Glucose uptake |
| Issue Date: | 1-Aug-2010 |
| Publisher: | Elsevier |
| Journal Title: | Bioorganic & Medicinal Chemistry Letters |
| Volume: | 20 |
| Issue: | 15 |
| Start Page: | 4333 |
| End Page: | 4336 |
| Publisher DOI: | 10.1016/j.bmcl.2010.06.077 |
| PMID: | 20605096 |
| Abstract: | Chemical treatment of diabetes mellitus is widely studied and controlling of blood glucose level is the main course of therapy. In type 2 diabetes mellitus, insulin resistance is the major problem. An isoflavone C-glucoside, puerarin (1), is known to enhance glucose uptake into the insulin sensitive cell and is thought to be a candidate for treatment of diabetes mellitus. We synthesized 1 and several derivatives to apply for the structure-activity relationship study. The result against 3T3-L1 adipocyte indicated that the C-glucoside part of 1 is unconcerned in its activity when tested in vitro and the main structure responsible for its activity was the isoflavone moiety. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/52134 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 加藤 英介
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