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Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds
Title: | Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds |
Authors: | Kato, Eisuke Browse this author →KAKEN DB | Kawabata, Jun Browse this author →KAKEN DB |
Keywords: | Puerarin | Isoflavone | Diabetes mellitus | PPARγ | Glucose uptake |
Issue Date: | 1-Aug-2010 |
Publisher: | Elsevier |
Journal Title: | Bioorganic & Medicinal Chemistry Letters |
Volume: | 20 |
Issue: | 15 |
Start Page: | 4333 |
End Page: | 4336 |
Publisher DOI: | 10.1016/j.bmcl.2010.06.077 |
PMID: | 20605096 |
Abstract: | Chemical treatment of diabetes mellitus is widely studied and controlling of blood glucose level is the main course of therapy. In type 2 diabetes mellitus, insulin resistance is the major problem. An isoflavone C-glucoside, puerarin (1), is known to enhance glucose uptake into the insulin sensitive cell and is thought to be a candidate for treatment of diabetes mellitus. We synthesized 1 and several derivatives to apply for the structure-activity relationship study. The result against 3T3-L1 adipocyte indicated that the C-glucoside part of 1 is unconcerned in its activity when tested in vitro and the main structure responsible for its activity was the isoflavone moiety. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/52134 |
Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 加藤 英介
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