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Identification of hydroxychavicol and its dimers, the lipase inhibitors contained in the Indonesian spice, Eugenia polyantha
| Title: | Identification of hydroxychavicol and its dimers, the lipase inhibitors contained in the Indonesian spice, Eugenia polyantha |
| Authors: | Kato, Eisuke Browse this author →KAKEN DB | | Nakagomi, Ryo Browse this author | | Gunawan-Puteri, Maria D. P. T. Browse this author | | Kawabata, Jun Browse this author →KAKEN DB |
| Keywords: | Eugenia polyantha | | Pancreatic lipase inhibitor | | Obesity | | Spice | | Jamu |
| Issue Date: | 15-Feb-2013 |
| Publisher: | Elsevier |
| Journal Title: | Food Chemistry |
| Volume: | 136 |
| Issue: | 3-4 |
| Start Page: | 1239 |
| End Page: | 1242 |
| Publisher DOI: | 10.1016/j.foodchem.2012.09.013 |
| PMID: | 23194519 |
| Abstract: | Inhibition of pancreatic lipase is effective for a prevention of obesity. Eugenia polyantha is a tropical tree whose leaves are known as a spice and also as an ingredient for Jamu, the traditional medicine of Indonesia. We found inhibitory activity against pancreatic lipase in the extract of E. polyantha leaves. Purification of the active principals resulted in isolation of hydroxychavicol, and two structurally new dimers. All of the isolated compounds showed inhibitory activity against the porcine pancreatic lipase and high content of hydroxychavicol (1.83 wt%) indicated this compound to be responsible for the majority of inhibitory activity of E. polyantha extract. Furthermore, hydroxychavicol is reported to possess anti-carcinogenic, anti-oxidant, anti-microbial and anti-inflammatory activity which is related to traditional usage of this plant. These results offer this plant as an attractive material for treating various health problems including obesity. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/52136 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 加藤 英介
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