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Identification of hydroxychavicol and its dimers, the lipase inhibitors contained in the Indonesian spice, Eugenia polyantha

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Title: Identification of hydroxychavicol and its dimers, the lipase inhibitors contained in the Indonesian spice, Eugenia polyantha
Authors: Kato, Eisuke Browse this author →KAKEN DB
Nakagomi, Ryo Browse this author
Gunawan-Puteri, Maria D. P. T. Browse this author
Kawabata, Jun Browse this author →KAKEN DB
Keywords: Eugenia polyantha
Pancreatic lipase inhibitor
Issue Date: 15-Feb-2013
Publisher: Elsevier
Journal Title: Food Chemistry
Volume: 136
Issue: 3-4
Start Page: 1239
End Page: 1242
Publisher DOI: 10.1016/j.foodchem.2012.09.013
PMID: 23194519
Abstract: Inhibition of pancreatic lipase is effective for a prevention of obesity. Eugenia polyantha is a tropical tree whose leaves are known as a spice and also as an ingredient for Jamu, the traditional medicine of Indonesia. We found inhibitory activity against pancreatic lipase in the extract of E. polyantha leaves. Purification of the active principals resulted in isolation of hydroxychavicol, and two structurally new dimers. All of the isolated compounds showed inhibitory activity against the porcine pancreatic lipase and high content of hydroxychavicol (1.83 wt%) indicated this compound to be responsible for the majority of inhibitory activity of E. polyantha extract. Furthermore, hydroxychavicol is reported to possess anti-carcinogenic, anti-oxidant, anti-microbial and anti-inflammatory activity which is related to traditional usage of this plant. These results offer this plant as an attractive material for treating various health problems including obesity.
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 英介

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