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Type-I Interferon is Critical for FasL Expression on Lung Cells to Determine the Severity of Influenza
This item is licensed under:Creative Commons Attribution 3.0 Unported
| Title: | Type-I Interferon is Critical for FasL Expression on Lung Cells to Determine the Severity of Influenza |
| Authors: | Fujikura, Daisuke Browse this author | | Chiba, Satoko Browse this author | | Muramatsu, Daisuke Browse this author | | Kazumata, Mika Browse this author | | Nakayama, Yosuke Browse this author | | Kawai, Taro Browse this author | | Akira, Shizuo Browse this author | | Kida, Hiroshi Browse this author →KAKEN DB | | Miyazaki, Tadaaki Browse this author →KAKEN DB |
| Issue Date: | 8-Feb-2013 |
| Publisher: | Public Library of Science |
| Journal Title: | PLoS One |
| Volume: | 8 |
| Issue: | 2 |
| Start Page: | e55321 |
| Publisher DOI: | 10.1371/journal.pone.0055321 |
| Abstract: | Infection of influenza A virus in mammals induces hyper lung pneumonia, which often causes lethal diseases. FasL is a specific ligand of Fas, which is a type-I transmembrane protein to induce cell death. Previously, it has been reported that the hyper induction of gene expression associated with Fas signal is observed in lethal influenza A virus infection. More importantly, it was also reported that functional mutation of the FasL gene protects the host against influenza A virus infection. These observations suggest that induction of FasL signal is functionally associated with the severity of influenza. However, regulation of the induction of FasL or Fas by influenza A virus infection is still unknown. Here, we demonstrated that FasL is induced after the viral infection, and inhibition of the Fas/FasL signal by treatment with a recombinant decoy receptor for FasL (Fas-Fc) increases the survival rate of mice after lethal infection of influenza A virus as well as functional mutation of the FasL gene in gld/gld mice. In addition, the induction level of FasL gene expression in the lung was correlated with the severity of influenza. We also showed that a variety of types of cells in the lung express FasL after the viral infection. Furthermore, type-I interferon induced by the viral infection was shown to be critical for induction of FasL protein expression in the lung. These findings suggested that expression of FasL protein induced by type-I IFN on the lung cell surface is critical to determine the severity of influenza. |
| Rights: | http://creativecommons.org/licenses/by/3.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/52234 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮崎 忠昭
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