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Type-I Interferon is Critical for FasL Expression on Lung Cells to Determine the Severity of Influenza

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Title: Type-I Interferon is Critical for FasL Expression on Lung Cells to Determine the Severity of Influenza
Authors: Fujikura, Daisuke Browse this author
Chiba, Satoko Browse this author
Muramatsu, Daisuke Browse this author
Kazumata, Mika Browse this author
Nakayama, Yosuke Browse this author
Kawai, Taro Browse this author
Akira, Shizuo Browse this author
Kida, Hiroshi Browse this author →KAKEN DB
Miyazaki, Tadaaki Browse this author →KAKEN DB
Issue Date: 8-Feb-2013
Publisher: Public Library of Science
Journal Title: PLoS One
Volume: 8
Issue: 2
Start Page: e55321
Publisher DOI: 10.1371/journal.pone.0055321
Abstract: Infection of influenza A virus in mammals induces hyper lung pneumonia, which often causes lethal diseases. FasL is a specific ligand of Fas, which is a type-I transmembrane protein to induce cell death. Previously, it has been reported that the hyper induction of gene expression associated with Fas signal is observed in lethal influenza A virus infection. More importantly, it was also reported that functional mutation of the FasL gene protects the host against influenza A virus infection. These observations suggest that induction of FasL signal is functionally associated with the severity of influenza. However, regulation of the induction of FasL or Fas by influenza A virus infection is still unknown. Here, we demonstrated that FasL is induced after the viral infection, and inhibition of the Fas/FasL signal by treatment with a recombinant decoy receptor for FasL (Fas-Fc) increases the survival rate of mice after lethal infection of influenza A virus as well as functional mutation of the FasL gene in gld/gld mice. In addition, the induction level of FasL gene expression in the lung was correlated with the severity of influenza. We also showed that a variety of types of cells in the lung express FasL after the viral infection. Furthermore, type-I interferon induced by the viral infection was shown to be critical for induction of FasL protein expression in the lung. These findings suggested that expression of FasL protein induced by type-I IFN on the lung cell surface is critical to determine the severity of influenza.
Type: article
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮崎 忠昭

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