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Characterization of extensively drug-resistant Mycobacterium tuberculosis in Nepal

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Title: Characterization of extensively drug-resistant Mycobacterium tuberculosis in Nepal
Authors: Poudel, Ajay Browse this author
Maharjan, Bhagwan Browse this author
Nakajima, Chie Browse this author →KAKEN DB
Fukushima, Yukari Browse this author
Pandey, Basu D. Browse this author
Beneke, Antje Browse this author
Suzuki, Yasuhiko Browse this author →KAKEN DB
Keywords: XDR
Tuberculosis
Nepal
Issue Date: Jan-2013
Publisher: Elsevier
Journal Title: Tuberculosis
Volume: 93
Issue: 1
Start Page: 84
End Page: 88
Publisher DOI: 10.1016/j.tube.2012.10.007
PMID: 23146281
Abstract: The emergence of extensively drug-resistant tuberculosis (XDR-TB) has raised public health concern for global control of TB. Although molecular characterization of drug resistance-associated mutations in multidrug-resistant isolates in Nepal has been made, mutations in XDR isolates and their genotypes have not been reported previously. In this study, we identified and characterized 13 XDR Mycobacterium tuberculosis isolates from clinical isolates in Nepal. The most prevalent mutations involved in rifampicin, isoniazid, ofloxacin, and kanamycin/capreomycin resistance were Ser531Leu in rpoB gene (92.3%), Ser315Thr in katG gene (92.3%), Asp94Gly in gyrA gene (53.9%) and A1400G in rrs gene (61.5%), respectively. Spoligotyping and multilocus sequence typing revealed that 69% belonged to Beijing family, especially modern types. Further typing with 26-loci variable number of tandem repeats suggested the current spread of XDR M. tuberculosis. Our result highlights the need to reinforce the TB policy in Nepal with regard to control and detection strategies.
Type: article (author version)
URI: http://hdl.handle.net/2115/52260
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 鈴木 定彦

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