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Clinical factor affecting the recovery of kidney function in clinically localized renal cell carcinoma patients who underwent nephron-sparing surgery.

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Title: Clinical factor affecting the recovery of kidney function in clinically localized renal cell carcinoma patients who underwent nephron-sparing surgery.
Authors: Osawa, Takahiro Browse this author
Harada, Hiroshi Browse this author
Oba, Koji Browse this author
Seki, Toshimori Browse this author
Togashi, Masaki Browse this author
Keywords: renal cell carcinoma
nephron-sparing surgery
renal function
chronic kidney disease
diabetes mellitus
Issue Date: Jan-2013
Publisher: 北海道医学会
Journal Title: 北海道医学雑誌 The Hokkaido journal of medical science
Volume: 88
Issue: 1
Start Page: 15
End Page: 20
PMID: 23461068
Abstract: INTRODUCTION:Nephron-sparing surgery (NSS) has become the standard treatment for small renal cell carcinoma because of its comparable oncological outcome and superior patient survival compared to total nephrectomy. However, the precise chronological course of recovery from initial kidney damage and the factors responsible for it remain unknown. MATERIALS AND METHODS:Seventy-one patients who underwent NSS were enrolled. To elucidate the chronological changes in kidney function that occur after NSS, the estimated glomerular filtration rate (eGFR) was calculated at different two points, the early (7 days after surgery) and late time points (more than 12 months after surgery), and compared with the preoperative eGFR. Perioperative factors were applied to a multivariate regression model to investigate the factors that most affect patient recovery from nephron damage. RESULTS:eGFR was decreased at the early time point but had partially recovered at the late time point. Male gender, ischemic time, and tumor size were found to be significant predictors of the initial drop in eGFR. The only significant factor that prevented later functional recovery was the presence of DM. CONCLUSION:Several perioperative factors significantly influence early kidney damage; however, the presence of DM is the only factor affecting the risk of long-term chronic kidney damage.
Type: article (author version)
URI: http://hdl.handle.net/2115/52582
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大澤 崇宏

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