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Changes in the viscoelastic properties of cortical bone by selective degradation of matrix protein
| Title: | Changes in the viscoelastic properties of cortical bone by selective degradation of matrix protein |
| Authors: | Shirakawa, Hideki Browse this author | | Furusawa, Kazuya Browse this author | | Fukui, Akimasa Browse this author | | Tadano, Shigeru Browse this author | | Sasaki, Naoki Browse this author →KAKEN DB |
| Keywords: | Viscoelasticity of bone | | Stress relaxation | | Relaxation time | | Matrix protein degradation |
| Issue Date: | 22-Feb-2013 |
| Publisher: | ELSEVIER |
| Journal Title: | Journal of Biomechanics |
| Volume: | 46 |
| Issue: | 4 |
| Start Page: | 696 |
| End Page: | 701 |
| Publisher DOI: | 10.1016/j.jbiomech.2012.11.038 |
| PMID: | 23261016 |
| Abstract: | We have studied stress relaxation of bovine femoral cortical bone specimens treated with KOH aqueous solution which had been known to degrade selectively protein molecules in bone. With the KOH treatment, we found an increase in specimens' volume. This increase was regarded as swelling of the bone specimen, presumably due to matrix protein network degradation including that of collagen. In an analogy of bone to gel structure, an increasing ratio of specimen volume was used as an indicating parameter for the matrix protein network degradation by the treatment. Although an empirical equation with a linearly combined form of two Kohlrausch-Williams-Watts (KWW) functions has been shown to describe the stress relaxation of bone specimens, a single KWW function was suitable for the bone specimens treated with KOH solution for as little as 3 h. In KOH treated specimens, both the initial modulus and the relaxation time decreased with the volume-increasing ratio, while the relaxation time distribution did not change. A chemo-rheological consideration attributed the reduction of modulus values to the network degradation in the organic matrix phase. The relaxation time of KOH treated specimens was thought to be related to the longer relaxation time of untreated bones, although there was a discontinuity between the extrapolated relaxation time values for KOH treated specimens and untreated specimens. This discontinuity may have originated from the release of residual stress existing in the bone by the matrix protein degradation. The results of the present study suggest that the state of matrix protein is crucial for integrating the mechanical properties of bone. (c) 2012 Elsevier Ltd. All rights reserved. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/52641 |
| Appears in Collections: | 生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 佐々木 直樹
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