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Inhibitory effects of dopamine on spinal synaptic transmission via dopamine D1-like receptors in neonatal rats

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Title: Inhibitory effects of dopamine on spinal synaptic transmission via dopamine D1-like receptors in neonatal rats
Authors: Kawamoto, K. Browse this author
Otsuguro, K. Browse this author →KAKEN DB
Ishizuka, M. Browse this author →KAKEN DB
Ito, S. Browse this author →KAKEN DB
Keywords: dopamine
dopamine D1-like receptors
spinal cord
reflex potentials
Issue Date: May-2012
Publisher: Blackwell Publishing
Journal Title: British Journal of Pharmacology
Volume: 166
Issue: 2
Start Page: 788
End Page: 800
Publisher DOI: 10.1111/j.1476-5381.2011.01815.x
Abstract: BACKGROUND AND PURPOSE: Dopamine released from the endings of descending dopaminergic fibre in the spinal cord is suggested to be involved in modulating functions such as locomotion and nociception. Here, we examined the effects of dopamine on spinal synaptic transmissions in rats. EXPERIMENTAL APPROACH: Spinal reflex potentials, monosynaptic reflex potential (MSR) and slow ventral root potential (sVRP), were measured in the isolated spinal cord of the neonatal rat. Dopamine release was measured by using HPLC. KEY RESULTS: Dopamine at lower concentrations (< 1 μM) depressed sVRP, which is C fibre-evoked polysynaptic response and believed to reflect nociceptive transmission. At higher concentrations (> 1 μM), in addition to a potent sVRP depression, dopamine depolarized baseline potential and slightly depressed MSR. Depression of sVRP by dopamine was partially reversed by dopamine D1-like but not by D2-like receptor antagonists. SKF83959 and SKF81297, D1-like receptor agonists, and methamphetamine, an endogenous dopamine releaser, also caused the inhibition of sVRP. Methamphetamine also depressed MSR, which was inhibited by ketanserin, a 5-HT_[2A/2C] receptor antagonist. Methamphetamine induced the release of dopamine and 5-HT from spinal cords, indicating that the release of endogenous dopamine and 5-HT depresses sVRP and MSR respectively. CONCLUSION AND IMPLICATIONS: These results suggest that dopamine at lower concentrations preferentially inhibits sVRP, which is mediated via D1-like and unidentified receptors. The dopamine-evoked depression is involved in modulating the spinal functions by the descending dopaminergic pathways.
Rights: The definitive version is available at
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 乙黒 兼一

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