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Stevioside enhances apoptosis induced by serum deprivation in PC12 cells

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Title: Stevioside enhances apoptosis induced by serum deprivation in PC12 cells
Authors: Takahashi, Kumiko Browse this author
Sun, Yongkun Browse this author
Yanagiuchi, Ikumi Browse this author
Hosokawa, Toshiyuki Browse this author →KAKEN DB
Saito, Takeshi Browse this author →KAKEN DB
Komori, Miyako Browse this author
Okino, Tatsufumi Browse this author →KAKEN DB
Kurasaki, Masaaki Browse this author →KAKEN DB
Keywords: Apoptosis
Bcl-2 family
cytochrome c
PC12 cells
Issue Date: May-2012
Publisher: Informa Healthcare
Journal Title: Toxicology Mechanisms and Methods
Volume: 22
Issue: 4
Start Page: 243
End Page: 249
Publisher DOI: 10.3109/15376516.2012.658978
PMID: 22316388
Abstract: In our laboratory, using a PC12 cell system, we have been conducting studies on the effects of various chemicals on apoptosis, as it is considered to be an essential part of normal development, maintenance, and defense in organisms. Stevioside is a natural sweetener extracted from the leaves of Stevia rebaudiana. Since it is widely used as a sugar replacement, we decided to evaluate the toxicological effects of low concentrations of stevioside on apoptosis induced by serum deprivation using the PC12 cell system. We found, based on data from DNA electrophoresis and TUNEL signal assays, that stevioside enhanced apoptosis induced by serum deprivation. This enhancement was caused by increased expression of bax and of cytochrome C released into the cytosol. These findings suggest that stevioside affects the regulation of the normal apoptotic condition. Further investigation will be needed to clarify the detailed the mechanism of the enhancement due to the treatment with stevioside.
Type: article (author version)
Appears in Collections:環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 藏崎 正明

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