| Title: | A comparison of oral mucositis in allogeneic hematopoietic stem cell transplantation between conventional and reduced-intensity regimens |
| Authors: | Kashiwazaki, Haruhiko Browse this author →KAKEN DB |
| Matsushita, Takae Browse this author |
| Sugita, Junichi Browse this author |
| Shigematsu, Akio Browse this author |
| Kasashi, Kumiko Browse this author |
| Yamazaki, Yutaka Browse this author →KAKEN DB |
| Kanehira, Takashi Browse this author →KAKEN DB |
| Kondo, Takeshi Browse this author →KAKEN DB |
| Endo, Tomoyuki Browse this author |
| Tanaka, Junji Browse this author →KAKEN DB |
| Hashino, Satoshi Browse this author →KAKEN DB |
| Nishio, Mitsufumi Browse this author →KAKEN DB |
| Imamura, Masahiro Browse this author →KAKEN DB |
| Kitagawa, Yoshimasa Browse this author →KAKEN DB |
| Inoue, Nobuo Browse this author →KAKEN DB |
| Keywords: | Hematopoietic stem cell transplantation |
| Oral mucositis |
| Reduced-intensity regimens |
| Issue Date: | May-2012 |
| Publisher: | Springer Berlin / Heidelberg |
| Journal Title: | Supportive Care in Cancer |
| Volume: | 20 |
| Issue: | 5 |
| Start Page: | 933 |
| End Page: | 939 |
| Publisher DOI: | 10.1007/s00520-011-1164-2 |
| PMID: | 21494780 |
| Abstract: | Goals of work: Severe oral mucositis developed in allogeneic hematopoietic stem cell transplantation (HSCT) accompanies intolerable pain and risk for systemic bacteremia infection. Conventional stem cell transplantation (CST) and reduced-intensity regimens for allogeneic HSCT (RIST) may differently affect the occurrence and severity of oral mucositis. Here, we comparatively examined oral mucositis in patients undergoing CST and that in RIST patients to search for measures to alleviate oral mucositis. Patients and methods: We retrospectively analyzed the data of 130 consecutive patients undergoing HSCT (conventional, 60; RIST, 70). Oral mucositis was evaluated according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) version 3.0. We also investigated risk factors for severe oral mucositis in each regimen. Main results: The incidence of oral mucositis was not significantly different between RIST and CST patients. Use of opioid analgesics to control pain due to oral mucositis was significantly less in patients undergoing RIST compared with those receiving CST. The risk factors for severe oral mucositis, determined by univariate and multivariate analyses, were "younger age (<40)" in CST and "longer duration of neutropenia (≥ 14 days)" in RIST. Conclusions: Although the incidences of oral mucositis were almost the same, the need for opioid analgesics and the risk factors for severe oral mucositis differed between CST and RIST patients. |
| Rights: | The final publication is available at www.springerlink.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/52721 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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