HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
Peer-reviewed Journal Articles, etc >

A comparison of oral mucositis in allogeneic hematopoietic stem cell transplantation between conventional and reduced-intensity regimens

Files in This Item:
SCC20-5_933-939.pdf645.49 kBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/52721

Title: A comparison of oral mucositis in allogeneic hematopoietic stem cell transplantation between conventional and reduced-intensity regimens
Authors: Kashiwazaki, Haruhiko Browse this author →KAKEN DB
Matsushita, Takae Browse this author
Sugita, Junichi Browse this author
Shigematsu, Akio Browse this author
Kasashi, Kumiko Browse this author
Yamazaki, Yutaka Browse this author →KAKEN DB
Kanehira, Takashi Browse this author →KAKEN DB
Kondo, Takeshi Browse this author →KAKEN DB
Endo, Tomoyuki Browse this author
Tanaka, Junji Browse this author →KAKEN DB
Hashino, Satoshi Browse this author →KAKEN DB
Nishio, Mitsufumi Browse this author →KAKEN DB
Imamura, Masahiro Browse this author →KAKEN DB
Kitagawa, Yoshimasa Browse this author →KAKEN DB
Inoue, Nobuo Browse this author →KAKEN DB
Keywords: Hematopoietic stem cell transplantation
Oral mucositis
Reduced-intensity regimens
Issue Date: May-2012
Publisher: Springer Berlin / Heidelberg
Journal Title: Supportive Care in Cancer
Volume: 20
Issue: 5
Start Page: 933
End Page: 939
Publisher DOI: 10.1007/s00520-011-1164-2
PMID: 21494780
Abstract: Goals of work: Severe oral mucositis developed in allogeneic hematopoietic stem cell transplantation (HSCT) accompanies intolerable pain and risk for systemic bacteremia infection. Conventional stem cell transplantation (CST) and reduced-intensity regimens for allogeneic HSCT (RIST) may differently affect the occurrence and severity of oral mucositis. Here, we comparatively examined oral mucositis in patients undergoing CST and that in RIST patients to search for measures to alleviate oral mucositis. Patients and methods: We retrospectively analyzed the data of 130 consecutive patients undergoing HSCT (conventional, 60; RIST, 70). Oral mucositis was evaluated according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) version 3.0. We also investigated risk factors for severe oral mucositis in each regimen. Main results: The incidence of oral mucositis was not significantly different between RIST and CST patients. Use of opioid analgesics to control pain due to oral mucositis was significantly less in patients undergoing RIST compared with those receiving CST. The risk factors for severe oral mucositis, determined by univariate and multivariate analyses, were "younger age (<40)" in CST and "longer duration of neutropenia (≥ 14 days)" in RIST. Conclusions: Although the incidences of oral mucositis were almost the same, the need for opioid analgesics and the risk factors for severe oral mucositis differed between CST and RIST patients.
Rights: The final publication is available at www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/52721
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 柏崎 晴彦

Export metadata:

OAI-PMH ( junii2 , jpcoar )


 

Feedback - Hokkaido University