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Molecular basis of the dopaminergic system in the cricket Gryllus bimaculatus

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Title: Molecular basis of the dopaminergic system in the cricket Gryllus bimaculatus
Authors: Watanabe, Takayuki Browse this author
Sadamoto, Hisayo Browse this author →KAKEN DB
Aonuma, Hitoshi Browse this author →KAKEN DB
Keywords: dopamine
tyrosine hydroxylase
dopamine receptors
high-affinity dopamine transporter
Gryllus bimaculatus
Issue Date: 2013
Publisher: Springer
Journal Title: Invertebrate neuroscience
Publisher DOI: 10.1007/s10158-013-0153-1
PMID: 23539475
Abstract: In insects, dopamine modulates various aspects of behavior such as learning and memory, arousal and locomotion, and is also a precursor of melanin. To elucidate the molecular basis of the dopaminergic system in the field cricket Gryllus bimaculatus DeGeer, we identified genes involved in dopamine biosynthesis, signal transduction, and dopamine re-uptake in the cricket. Complementary DNA of two isoforms of tyrosine hydroxylase (TH), which convert tyrosine into l-3,4-dihydroxyphenylalanine, was isolated from the cricket brain cDNA library. In addition, four dopamine receptor genes (Dop1, Dop2, Dop3, and DopEcR) and a high-affinity dopamine transporter gene were identified. The two TH isoforms contained isoform-specific regions in the regulatory ACT domain and showed differential expression patterns in different tissues. In addition, the dopamine receptor genes had a receptor subtype-specific distribution: the Dop1, Dop2, and DopEcR genes were broadly expressed in various tissues at differential expression levels, and the Dop3 gene was restrictedly expressed in neuronal tissues and the testicles. Our findings provide a fundamental basis for understanding the dopaminergic regulation of diverse physiological processes in the cricket.
Type: article (author version)
Appears in Collections:電子科学研究所 (Research Institute for Electronic Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 青沼 仁志

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