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Endogenously released 5-HT inhibits A and C fiber-evoked synaptic transmission in the rat spinal cord by the facilitation of GABA/glycine and 5-HT release via 5-HT2A and 5-HT3 receptors

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/52751

Title: Endogenously released 5-HT inhibits A and C fiber-evoked synaptic transmission in the rat spinal cord by the facilitation of GABA/glycine and 5-HT release via 5-HT2A and 5-HT3 receptors
Authors: Iwasaki, Takeyuki Browse this author
Otsuguro, Ken-ichi Browse this author →KAKEN DB
Kobayashi, Takeshi Browse this author
Ohta, Toshio Browse this author →KAKEN DB
Ito, Shigeo Browse this author →KAKEN DB
Keywords: 5-HT
Spinal reflex potential
GABA
Glycine
Autoreceptor
Issue Date: 28-Feb-2013
Publisher: Elsevier
Journal Title: European Journal of Pharmacology
Volume: 702
Issue: 1-3
Start Page: 149
End Page: 157
Publisher DOI: 10.1016/j.ejphar.2013.01.058
PMID: 23399761
Abstract: Serotonin (5-HT) released from descending fibers plays important roles in spinal functions such as locomotion and nociception. 5-HT2A and 5-HT3 receptors are suggested to contribute to spinal antinociception, although their activation also contributes to neuronal excitation. In the neonatal spinal cord, DL-p-chloroamphetamine (pCA), a 5-HT releaser, inhibited both A fiber-evoked monosynaptic reflex potential (MSR) and C fiber-evoked slow ventral root potential (sVRP). The pCA-mediated inhibition was reversed by ketanserin (a 5-HT2A receptor antagonist) and tropisetron (a 5-HT3 receptor antagonist). Bath-applied 5-HT also inhibited MSR and sVRP; in this case, the actions of 5-HT were antagonized by ketanserin, but not by tropisetron. The pCA-evoked inhibition of sVRP was reduced by bicuculline (a GABA(A) receptor antagonist) and strychnine (a glycine receptor antagonist). Furthermore, ketanserin inhibited the pCA-evoked release of gamma-aminobutyric acid (GABA) and glycine, while tropisetron inhibited the pCA-evoked release of 5-HT. These results suggest that 5-HT released by pCA activates 5-HT2A receptors, which in turn stimulates the release of GABA/glycine and thereby blocks the spinal nociceptive pathway. 5-HT3 receptors may be involved in the facilitation of 5-HT release via a positive feedback process. (C) 2013 Elsevier B.V. All rights reserved.
Relation: http://www.sciencedirect.com/science/article/pii/S0014299913000782
Type: article (author version)
URI: http://hdl.handle.net/2115/52751
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 乙黒 兼一

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