Title: | What is the appropriate size criterion for proton radiotherapy for hepatocellular carcinoma? A dosimetric comparison of spot-scanning proton therapy versus intensity-modulated radiation therapy |
Authors: | Toramatsu, Chie Browse this author |
Katoh, Norio Browse this author →KAKEN DB |
Shimizu, Shinichi Browse this author →KAKEN DB |
Nihongi, Hideaki Browse this author |
Matsuura, Taeko Browse this author →KAKEN DB |
Takao, Seishin Browse this author →KAKEN DB |
Miyamoto, Naoki Browse this author →KAKEN DB |
Suzuki, Ryusuke Browse this author →KAKEN DB |
Sutherland, Kenneth Browse this author →KAKEN DB |
Kinoshita, Rumiko Browse this author →KAKEN DB |
Onimaru, Rikiya Browse this author →KAKEN DB |
Ishikawa, Masayori Browse this author →KAKEN DB |
Umegaki, Kikuo Browse this author →KAKEN DB |
Shirato, Hiroki Browse this author →KAKEN DB |
Keywords: | Spot-scanning proton therapy |
Intensity-modulated radiation therapy |
Hepatocellular carcinoma |
Radiation induced liver disease |
Issue Date: | 5-Mar-2013 |
Publisher: | BioMed Central |
Journal Title: | Radiation Oncology |
Volume: | 8 |
Start Page: | 48 |
Publisher DOI: | 10.1186/1748-717X-8-48 |
Abstract: | Background: We performed a dosimetric comparison of spot-scanning proton therapy (SSPT) and intensity-modulated radiation therapy (IMRT) for hepatocellular carcinoma (HCC) to investigate the impact of tumor size on the risk of radiation induced liver disease (RILD). Methods: A number of alternative plans were generated for 10 patients with HCC. The gross tumor volumes (GTV) varied from 20.1 to 2194.5 cm(3). Assuming all GTVs were spherical, the nominal diameter was calculated and ranged from 3.4 to 16.1 cm. The prescription dose was 60 Gy for IMRT or 60 cobalt Gy-equivalents for SSPT with 95% planning target volume (PTV) coverage. Using IMRT and SSPT techniques, extensive comparative planning was conducted. All plans were evaluated by the risk of RILD estimated using the Lyman-normal-tissue complication probability model. Results: For IMRT the risk of RILD increased drastically between 6.3-7.8 cm nominal diameter of GTV. When the nominal diameter of GTV was more than 6.3 cm, the average risk of RILD was 94.5% for IMRT and 6.2% for SSPT. Conclusions: Regarding the risk of RILD, HCC can be more safely treated with SSPT, especially if its nominal diameter is more than 6.3 cm. |
Rights: | http://creativecommons.org/licenses/by/2.0/ |
Type: | article |
URI: | http://hdl.handle.net/2115/52762 |
Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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