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What is the appropriate size criterion for proton radiotherapy for hepatocellular carcinoma? A dosimetric comparison of spot-scanning proton therapy versus intensity-modulated radiation therapy

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Title: What is the appropriate size criterion for proton radiotherapy for hepatocellular carcinoma? A dosimetric comparison of spot-scanning proton therapy versus intensity-modulated radiation therapy
Authors: Toramatsu, Chie Browse this author
Katoh, Norio Browse this author →KAKEN DB
Shimizu, Shinichi Browse this author →KAKEN DB
Nihongi, Hideaki Browse this author
Matsuura, Taeko Browse this author →KAKEN DB
Takao, Seishin Browse this author →KAKEN DB
Miyamoto, Naoki Browse this author →KAKEN DB
Suzuki, Ryusuke Browse this author →KAKEN DB
Sutherland, Kenneth Browse this author →KAKEN DB
Kinoshita, Rumiko Browse this author →KAKEN DB
Onimaru, Rikiya Browse this author →KAKEN DB
Ishikawa, Masayori Browse this author →KAKEN DB
Umegaki, Kikuo Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Keywords: Spot-scanning proton therapy
Intensity-modulated radiation therapy
Hepatocellular carcinoma
Radiation induced liver disease
Issue Date: 5-Mar-2013
Publisher: BioMed Central
Journal Title: Radiation Oncology
Volume: 8
Publisher DOI: 10.1186/1748-717X-8-48
Abstract: Background: We performed a dosimetric comparison of spot-scanning proton therapy (SSPT) and intensity-modulated radiation therapy (IMRT) for hepatocellular carcinoma (HCC) to investigate the impact of tumor size on the risk of radiation induced liver disease (RILD). Methods: A number of alternative plans were generated for 10 patients with HCC. The gross tumor volumes (GTV) varied from 20.1 to 2194.5 cm(3). Assuming all GTVs were spherical, the nominal diameter was calculated and ranged from 3.4 to 16.1 cm. The prescription dose was 60 Gy for IMRT or 60 cobalt Gy-equivalents for SSPT with 95% planning target volume (PTV) coverage. Using IMRT and SSPT techniques, extensive comparative planning was conducted. All plans were evaluated by the risk of RILD estimated using the Lyman-normal-tissue complication probability model. Results: For IMRT the risk of RILD increased drastically between 6.3-7.8 cm nominal diameter of GTV. When the nominal diameter of GTV was more than 6.3 cm, the average risk of RILD was 94.5% for IMRT and 6.2% for SSPT. Conclusions: Regarding the risk of RILD, HCC can be more safely treated with SSPT, especially if its nominal diameter is more than 6.3 cm.
Rights: http://creativecommons.org/licenses/by/2.0/
Type: article
URI: http://hdl.handle.net/2115/52762
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 徳雄

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