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Responses of insulin-like growth factor (IGF)-I and two IGF-binding protein-1 subtypes to fasting and re-feeding, and their relationships with individual growth rates in yearling masu salmon (Oncorhynchus masou)

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Title: Responses of insulin-like growth factor (IGF)-I and two IGF-binding protein-1 subtypes to fasting and re-feeding, and their relationships with individual growth rates in yearling masu salmon (Oncorhynchus masou)
Authors: Kawaguchi, Kohei Browse this author
Kaneko, Nobuto Browse this author
Fukuda, Miki Browse this author
Nakano, Yusuke Browse this author
Kimura, Shizuo Browse this author
Hara, Akihiko Browse this author →KAKEN DB
Shimizu, Munetaka Browse this author →KAKEN DB
Keywords: Insulin-like growth factor (IGF)-I
IGF-binding protein
Growth
Fasting
Index
Salmon
Issue Date: Jun-2013
Publisher: Elsevier
Journal Title: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
Volume: 165
Issue: 2
Start Page: 191
End Page: 198
Publisher DOI: 10.1016/j.cbpa.2013.02.029
PMID: 23474252
Abstract: Two subtypes of insulin-like growth factor binding protein (IGFBP)-1 are present in salmon blood and they are both up-regulated under catabolic conditions such as stress. The present study examined effects of fasting and re-feeding on IGFBP-1a (28-kDa form) and IGFBP-1b (22-kDa form) both at mRNA and protein levels along with IGF-I and RNA/DNA ratio in yearling masu salmon. Fish were individually tagged and assigned to one of three treatments: Fed, Fasted or Re-fed. Circulating IGF-I levels significantly decreased after fasting for 5 weeks and were positively correlated with individual growth rates. Liver igf-1 mRNA levels were not affected by the treatment. Muscle RNA/DNA ratio did not respond to fasting nor showed correlations with growth rates. Circulating IGFBP-1a and IGFBP-1b increased during fasting and decreased after re-feeding. Both serum levels were inversely correlated with growth rates, while IGFBP-1b had consistent negative relationships with growth rates. Fasting/re-feeding also affected their mRNA levels in the liver. These results suggest that circulating IGF-I and IGFBP-1b could serve as positive and negative indices of growth, respectively, in masu salmon. Different sensitivities of IGBP-1a and IGFBP-1b may be useful to assess a broad range of catabolic conditions when they are combined.
Type: article (author version)
URI: http://hdl.handle.net/2115/52768
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 清水 宗敬

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