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CD133 Negatively Regulates Tumorigenicity via AKT Pathway in Synovial Sarcoma
| Title: | CD133 Negatively Regulates Tumorigenicity via AKT Pathway in Synovial Sarcoma |
| Authors: | Kimura, Taichi Browse this author →KAKEN DB | | Wang, Lei Browse this author | | Tabu, Kouichi Browse this author | | Nishihara, Hiroshi Browse this author →KAKEN DB | | Mashita, Yuji Browse this author | | Kikuchi, Naoyuki Browse this author | | Tanino, Mishie Browse this author | | Hiraga, Hiroaki Browse this author | | Tanaka, Shinya Browse this author →KAKEN DB |
| Keywords: | Synovial sarcoma | | Cancer stem cell | | CD133 |
| Issue Date: | Jun-2012 |
| Publisher: | Informa Healthcare |
| Journal Title: | Cancer Investigation |
| Volume: | 30 |
| Issue: | 5 |
| Start Page: | 390 |
| End Page: | 397 |
| Publisher DOI: | 10.3109/07357907.2012.672607 |
| PMID: | 22571340 |
| Abstract: | Synovial sarcoma is an aggressive tumor which accounts for almost 10% of all soft tissue sarcomas. In this study, we found the expression of CD133 in human synovial sarcoma specimens, thus we focused on the function of CD133 in synovial sarcoma. Separation of the CD133-positive and -negative subpopulations in synovial sarcoma cell lines clarified that the CD133-negative subpopulation exhibited enhanced growth and hyperphosphorylation of AKT. Treatment of Akt inhibitor suppressed the cell growth of CD133-negative subpopulation to the levels of CD133-positive cells. These results suggest that CD133 has negative effect on the growth of cells through AKT-dependent signalling pathway. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/52796 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 木村 太一
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