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CD133 Negatively Regulates Tumorigenicity via AKT Pathway in Synovial Sarcoma

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Title: CD133 Negatively Regulates Tumorigenicity via AKT Pathway in Synovial Sarcoma
Authors: Kimura, Taichi Browse this author →KAKEN DB
Wang, Lei Browse this author
Tabu, Kouichi Browse this author
Nishihara, Hiroshi Browse this author →KAKEN DB
Mashita, Yuji Browse this author
Kikuchi, Naoyuki Browse this author
Tanino, Mishie Browse this author
Hiraga, Hiroaki Browse this author
Tanaka, Shinya Browse this author →KAKEN DB
Keywords: Synovial sarcoma
Cancer stem cell
Issue Date: Jun-2012
Publisher: Informa Healthcare
Journal Title: Cancer Investigation
Volume: 30
Issue: 5
Start Page: 390
End Page: 397
Publisher DOI: 10.3109/07357907.2012.672607
PMID: 22571340
Abstract: Synovial sarcoma is an aggressive tumor which accounts for almost 10% of all soft tissue sarcomas. In this study, we found the expression of CD133 in human synovial sarcoma specimens, thus we focused on the function of CD133 in synovial sarcoma. Separation of the CD133-positive and -negative subpopulations in synovial sarcoma cell lines clarified that the CD133-negative subpopulation exhibited enhanced growth and hyperphosphorylation of AKT. Treatment of Akt inhibitor suppressed the cell growth of CD133-negative subpopulation to the levels of CD133-positive cells. These results suggest that CD133 has negative effect on the growth of cells through AKT-dependent signalling pathway.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 木村 太一

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