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Mass preparation of oligosaccharides by the hydrolysis of chondroitin sulfate polysaccharides with a subcritical water microreaction system

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Title: Mass preparation of oligosaccharides by the hydrolysis of chondroitin sulfate polysaccharides with a subcritical water microreaction system
Authors: Yamada, Shuhei Browse this author
Matsushima, Keiichiro Browse this author
Ura, Haruo Browse this author
Miyamoto, Nobuyuki Browse this author
Sugahara, Kazuyuki Browse this author →KAKEN DB
Keywords: Chondroitin sulfate
Hydrolysis
Microreaction system
Oligosaccharides
Subcritical water
Issue Date: 19-Apr-2013
Publisher: Elsevier
Journal Title: Carbohydrate Research
Volume: 371
Start Page: 16
End Page: 21
Publisher DOI: 10.1016/j.carres.2013.01.024
PMID: 23454651
Abstract: The biological functions of chondroitin sulfate (CS) are executed by the interaction of specific oligosaccharide sequences in the polysaccharide chain with effective proteins. Thus, CS oligosaccharides are expected to have pharmacological applications. Furthermore, the demand for CS in health food supplements and medication is growing. However, the absorbency of CS polysaccharides in the digestive system is very low. Since the activity of orally administered CS is expected to increase by depolymerization, industrial production of CS oligosaccharides is required. In this study, hydrolysis with subcritical and super-critical water was applied to the depolymerization of CS for the first time, and hydrolytic conditions for oligosaccharide production were examined. CS oligosaccharides principally containing an N-acetyl-D-galactosamine residue at their reducing ends were successfully obtained. No significant desulfation was found in CS oligosaccharides prepared under optimized conditions. The production of CS oligosaccharides by this method will have a strong influence on the CS-related materials market. (C) 2013 Elsevier Ltd. All rights reserved.
Type: article (author version)
URI: http://hdl.handle.net/2115/52806
Appears in Collections:生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 菅原 一幸

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