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Volume 61 Number 1&2 >

Inhibition of influenza A virus infection by Galectin-9

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Title: Inhibition of influenza A virus infection by Galectin-9
Authors: Hattori, Tomoe Browse this author
Arikawa, Tomohiro Browse this author
Fujioka, Yoichiro Browse this author
Maruyama, Junki Browse this author
Nakayama, Yousuke Browse this author
Ohba, Yusuke Browse this author →KAKEN DB
Niki, Toshiro Browse this author
Miyazaki, Tadaaki Browse this author →KAKEN DB
Hirashima, Mitsuomi Browse this author
Kida, Hiroshi Browse this author →KAKEN DB
Keywords: Gal-9
influenza A virus
inhibition of viral growth
Issue Date: May-2013
Publisher: Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 61
Issue: 1&2
Start Page: 5
End Page: 18
Abstract: Galectin-9 (Gal-9) inhibited the infection of H1N1, H3N2 and H5N1 influenza A viruses in vitro and in vivo. Fifty percent effective doses (ED50) of Gal-9 were 0.1-0.5 M depending on virus strains in the plaque reduction assay. Gal-9 but not Gal-1 bound to the virus particles of A/Puerto Rico/8/34 (H1N1) (PR/8), resulting in inhibition of virus attachment to the host cells. Lactose but not sucrose inhibited the binding of Gal-9 to the viruses. Endogenous Gal-9 expression was detected and increased with the course of infection with influenza A viruses in mice. Fifty percent of Gal-9-transgenic mice survived after the challenge with PR/8, while all of the wild-type mice died. Gal-9 treatment of mice affected diminishing influenza virus replication in the lungs, body weight loss and the expression level of inflammatory cytokines. Combined administration of Gal-9 and oseltamivir was more effective than the use of single compound in mouse model. The present results indicate that Gal-9 is a candidate compound for influenza A virus infection therapy.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 61 Number 1&2

Submitter: 獣医学部図書室

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