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Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women

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Title: Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women
Authors: Kobayashi, Sumitaka Browse this author →KAKEN DB
Sata, Fumihiro Browse this author
Sasaki, Seiko Browse this author →KAKEN DB
Ban, Susumu Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Okada, Emiko Browse this author →KAKEN DB
Limpar, Mariko Browse this author
Yoshioka, Eiji Browse this author →KAKEN DB
Kajiwara, Jumboku Browse this author
Todaka, Takashi Browse this author
Saijo, Yasuaki Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Aromatic hydrocarbon receptor
Cytochrome P450
Single-nucleotide polymorphism
Dioxin
Blood
Issue Date: 7-Jun-2013
Publisher: Elsevier
Journal Title: Toxicology Letters
Volume: 219
Issue: 3
Start Page: 269
End Page: 278
Publisher DOI: 10.1016/j.toxlet.2013.03.013
PMID: 23528250
Abstract: Dioxins are metabolized by cytochrome P450, family 1 (CYP1) via the aromatic hydrocarbon receptor (AHR). We determined whether different blood dioxin concentrations are associated with polymorphisms in AHR (dbSNP ID: rs2066853), AHR repressor (AHRR; rs2292596), CYP1 subfamily A polypeptide 1 (CYP1A1; rs4646903 and rs1048963), CYP1 subfamily A polypeptide 2 (CYP1A2; rs762551), and CYP1 subfamily B polypeptide 1 (CYP1B1; rs1056836) in pregnant Japanese women. These six polymorphisms were detected in 421 healthy pregnant Japanese women. Differences in dioxin exposure concentrations in maternal blood among the genotypes were investigated. Comparisons among the GG, GA, and AA genotypes of AHR showed a significant difference (genotype model: P = 0.016 for the mono-ortho polychlorinated biphenyl concentrations and toxicity equivalence quantities [TEQs]). Second, we found a significant association with the dominant genotype model ([TT + TC] vs. CC: P = 0.048 for the polychlorinated dibenzo-p-dioxin TEQs; P = 0.035 for polychlorinated dibenzofuran TEQs) of CYP1A1 (rs4646903). No significant differences were found among blood dioxin concentrations and polymorphisms in AHRR, CYP1A1 (rs1048963), CYP1A2, and CYP1B1. Thus, polymorphisms in AHR and CYP1A1 (rs4646903) were associated with maternal dioxin concentrations. However, differences in blood dioxin concentrations were relatively low.
Type: article (author version)
URI: http://hdl.handle.net/2115/52913
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小林 澄貴

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