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Diethyl Phthalate Enhances Apoptosis Induced by Serum Deprivation in PC12 Cells

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/52985

Title: Diethyl Phthalate Enhances Apoptosis Induced by Serum Deprivation in PC12 Cells
Authors: Sun, Yongkun Browse this author
Takahashi, Kumiko Browse this author
Hosokawa, Toshiyuki Browse this author →KAKEN DB
Saito, Takeshi Browse this author →KAKEN DB
Kurasaki, Masaaki Browse this author →KAKEN DB
Keywords: Diethyl phthalate
Apoptosis
Caspase
Cytochrome C
PC12 cell
Issue Date: Aug-2012
Publisher: Wiley-Blackwell
Journal Title: Basic & Clinical Pharmacology & Toxicology
Volume: 111
Issue: 2
Start Page: 113
End Page: 119
Publisher DOI: 10.1111/j.1742-7843.2012.00869.x
PMID: 22348465
Abstract: In this study, to examine the mechanism of diethyl phthalate toxicity to cells, the effects of diethyl phthalate on apoptosis in a PC12 cell system were investigated by assaying apoptotic factors such as caspase-3, Bax, cytochrome c and DNA damage. Diethyl phthalate was shown to enhance the apoptosis induced by serum deprivation according to the results of DNA electrophoresis and TUNEL signal assays, although it could not induce apoptosis itself in the cells. This enhancement was thought to be because of an increase in caspase-3-like activity. In addition, the expression of bax and contents of cytochrome c in the cytosol showed a tendency to increase the cells exposed to diethyl phthalate. These results indicated that diethyl phthalate, a potential endocrine disrupter, affects the apoptotic system in PC12 cells. Diethyl phthalate may enhance oxidative stress such as that induced by reactive oxygen species in PC12 cells.
Type: article (author version)
URI: http://hdl.handle.net/2115/52985
Appears in Collections:環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 藏崎 正明

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