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Osteoconductivity and Biodegradability of Collagen Scaffold Coated with Nano-β-TCP and Fibroblast Growth Factor 2

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Title: Osteoconductivity and Biodegradability of Collagen Scaffold Coated with Nano-β-TCP and Fibroblast Growth Factor 2
Authors: Ibara, Asako Browse this author
Miyaji, Hirofumi Browse this author →KAKEN DB
Fugetsu, Bunshi Browse this author →KAKEN DB
Nishida, Erika Browse this author
Takita, Hiroko Browse this author →KAKEN DB
Tanaka, Saori Browse this author →KAKEN DB
Sugaya, Tsutomu Browse this author →KAKEN DB
Kawanami, Masamitsu Browse this author →KAKEN DB
Issue Date: 2013
Publisher: Hindawi Publishing Corporation
Journal Title: Journal of Nanomaterials
Volume: 2013
Start Page: 1
End Page: 11
Publisher DOI: 10.1155/2013/639502
Abstract: Nanoparticle bioceramics have become anticipated for biomedical applications.Highly bioactive and biodegradable scaffoldswould be developed using nanoparticles of 𝛽-tricalcium phosphate (𝛽-TCP).We prepared collagen scaffolds coated by nano-𝛽-TCP and fibroblast growth factor 2 (FGF2) and evaluated the effects on new bone augmentation and biodegradation. The collagen sponge was coated with the nano-TCP dispersion and freeze-dried. Scaffold was characterized by SEM, TEM, XRD, compressive testing and cell seeding. Subsequently, the nano-𝛽-TCP/collagen scaffold, collagen sponge, and each material loaded with FGF2 were implanted on rat cranial bone. As a control, no implantation was performed. Nano-TCP particles were found to be attached to the fibers of the collagen sponge by SEM and TEM observations. Scaffold coated with nano-TCP showed higher compressive strength and cytocompatibility. In histological evaluations at 10 days, inflammatory cells were rarely seen around the residual scaffold, suggesting that the nano-TCPmaterial possesses good tissue compatibility. At 35 days, bone augmentation and scaffold degradation in histological samples receiving nano-𝛽-TCP scaffold were significantly greater than those in the control. By loading of FGF2, advanced bone formation is facilitated, indicating that a combination with FGF2 would be effective for bone tissue engineering.
Rights: 2.1/jp/
Type: article
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮治 裕史

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