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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
Peer-reviewed Journal Articles, etc >
Osteoconductivity and Biodegradability of Collagen Scaffold Coated with Nano-β-TCP and Fibroblast Growth Factor 2
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| Title: | Osteoconductivity and Biodegradability of Collagen Scaffold Coated with Nano-β-TCP and Fibroblast Growth Factor 2 |
| Authors: | Ibara, Asako Browse this author | | Miyaji, Hirofumi Browse this author →KAKEN DB | | Fugetsu, Bunshi Browse this author →KAKEN DB | | Nishida, Erika Browse this author | | Takita, Hiroko Browse this author →KAKEN DB | | Tanaka, Saori Browse this author →KAKEN DB | | Sugaya, Tsutomu Browse this author →KAKEN DB | | Kawanami, Masamitsu Browse this author →KAKEN DB |
| Issue Date: | 2013 |
| Publisher: | Hindawi Publishing Corporation |
| Journal Title: | Journal of Nanomaterials |
| Volume: | 2013 |
| Start Page: | 1 |
| End Page: | 11 |
| Publisher DOI: | 10.1155/2013/639502 |
| Abstract: | Nanoparticle bioceramics have become anticipated for biomedical applications.Highly bioactive and biodegradable scaffoldswould be developed using nanoparticles of 𝛽-tricalcium phosphate (𝛽-TCP).We prepared collagen scaffolds coated by nano-𝛽-TCP and fibroblast growth factor 2 (FGF2) and evaluated the effects on new bone augmentation and biodegradation. The collagen sponge was coated with the nano-TCP dispersion and freeze-dried. Scaffold was characterized by SEM, TEM, XRD, compressive testing and cell seeding. Subsequently, the nano-𝛽-TCP/collagen scaffold, collagen sponge, and each material loaded with FGF2 were implanted on rat cranial bone. As a control, no implantation was performed. Nano-TCP particles were found to be attached to the fibers of the collagen sponge by SEM and TEM observations. Scaffold coated with nano-TCP showed higher compressive strength and cytocompatibility. In histological evaluations at 10 days, inflammatory cells were rarely seen around the residual scaffold, suggesting that the nano-TCPmaterial possesses good tissue compatibility. At 35 days, bone augmentation and scaffold degradation in histological samples receiving nano-𝛽-TCP scaffold were significantly greater than those in the control. By loading of FGF2, advanced bone formation is facilitated, indicating that a combination with FGF2 would be effective for bone tissue engineering. |
| Rights: | http://creativecommons.org/licenses/by-ncsa/ 2.1/jp/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/52991 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮治 裕史
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