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Genetic and Biological Characterization of Tick-Borne Encephalitis Virus Isolated from Wild Rodents in Southern Hokkaido, Japan in 2008

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/53028

Title: Genetic and Biological Characterization of Tick-Borne Encephalitis Virus Isolated from Wild Rodents in Southern Hokkaido, Japan in 2008
Authors: Kentaro, Yoshii Browse this author →KAKEN DB
Yamazaki, Shoko Browse this author
Mottate, Keita Browse this author
Nagata, Noriyo Browse this author →KAKEN DB
Seto, Takahiro Browse this author
Sanada, Takashiro Browse this author
Sakai, Mizuki Browse this author
Kariwa, Hiroaki Browse this author →KAKEN DB
Takashima, Ikuo Browse this author →KAKEN DB
Keywords: Tick-borne encephalitis virus
Oshima 08-As
Oshima 5-10
Hokkaido
Issue Date: Jun-2013
Publisher: Mary Ann Liebert Inc
Journal Title: Vector-Borne And Zoonotic Diseases
Volume: 13
Issue: 6
Start Page: 406
End Page: 414
Publisher DOI: 10.1089/vbz.2012.1231
Abstract: Tick-borne encephalitis virus (TBEV) is a zoonotic agent causing severe encephalitis in humans. A recent epizootiological survey indicated that endemic foci of TBEV have been maintained in the southern part of Hokkaido until recently. In this study, we sought to isolate TBEV from wild rodents in the area. One virus, designated Oshima 08-As, was isolated from an Apodemus speciosus captured in Hokuto in 2008. Oshima 08-As was classified as the Far Eastern subtype of TBEV and formed a cluster with the other strains isolated in Hokkaido from 1995 to 1996. Thirty-six nucleotide differences resulted in 12 amino acid changes between Oshima 08-As and Oshima 5-10 isolated in 1995. Oshima 08-As caused high mortality and morbidity in a mouse model compared with Oshima 5-10. Although similar transient viral multiplication in the spleen was observed in the mice infected with Oshima 08-As and Oshima 5-10, greater viral multiplication with an inflammatory response was noted in the brains of mice infected with Oshima 08-As than those infected with Oshima 5-10. These data indicate that a few naturally occurring mutations affect the pathogenicity of the Oshima strains endemic in the southern part of Hokkaido.
Type: article
URI: http://hdl.handle.net/2115/53028
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 好井 健太朗

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OAI-PMH ( junii2 , jpcoar )


 

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