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Difference in the D-dimer rise between women with singleton and multifetal pregnancies
| Title: | Difference in the D-dimer rise between women with singleton and multifetal pregnancies |
| Authors: | Yamada, Takashi Browse this author →KAKEN DB | | Kawaguchi, Satoshi Browse this author | | Araki, Naoto Browse this author | | Takeda, Masamitsu Browse this author | | Nishida, Ryutaro Browse this author | | Yamada, Takahiro Browse this author →KAKEN DB | | Morikawa, Mamoru Browse this author →KAKEN DB | | Minakami, Hisanori Browse this author →KAKEN DB |
| Keywords: | D-dimer | | Twin | | Pregnancy | | Venous thromboembolism |
| Issue Date: | Jun-2013 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Journal Title: | Thrombosis Research |
| Volume: | 131 |
| Issue: | 6 |
| Start Page: | 493 |
| End Page: | 496 |
| Publisher DOI: | 10.1016/j.thromres.2013.04.029 |
| PMID: | 23726968 |
| Abstract: | Introduction: The differences in the D-dimer rise between women with singleton and multifetal pregnancies have not been studied extensively. Materials and Methods: D-Dimer levels were determined in 1089 blood specimens from 1089 women in various stages of pregnancy, including 977 and 112 women with singleton and multifetal pregnancies, respectively. None of the 1089 women developed hypertension or clinical venous thromboembolism during pregnancy or in the postpartum period. Results: The D-dimer levels were significantly and positively correlated with gestational week at examination in women with singleton or multifetal pregnancies. The D-dimer levels (mu g/ml, mean +/- SD [number of specimens]) determined at the 1st trimester did not differ significantly (0.81 +/- 0.82 [102] for singleton vs. 1.20 +/- 0.77 [7] for multifetal), but those at the 2nd (1.61 +/- 1.45 [216] vs. 2.62 +/- 2.26 [59]) and 3rd (2.37 +/- 2.22 [659] vs. 4.02 +/- 2.14 [46]) trimesters were significantly higher in women with multifetal than singleton pregnancies. The 90th percentile value was 4.31 mu g/ml for 1089 specimens. A significantly greater number of women exceeded 4.31 mu g/ml during the 2nd (16.9% vs. 5.6%, P = 0.0043) and 3rd (34.8% vs. 10.6%, P < 0.0001) trimesters among those with multifetal than with singleton pregnancies. Conclusions: The degree of D-dimer rise in pregnancy was greater in women with multifetal than with singleton pregnancies. (C) 2013 Elsevier Ltd. All rights reserved. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/53075 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 水上 尚典
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