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Difference in the D-dimer rise between women with singleton and multifetal pregnancies

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Title: Difference in the D-dimer rise between women with singleton and multifetal pregnancies
Authors: Yamada, Takashi Browse this author →KAKEN DB
Kawaguchi, Satoshi Browse this author
Araki, Naoto Browse this author
Takeda, Masamitsu Browse this author
Nishida, Ryutaro Browse this author
Yamada, Takahiro Browse this author →KAKEN DB
Morikawa, Mamoru Browse this author →KAKEN DB
Minakami, Hisanori Browse this author →KAKEN DB
Keywords: D-dimer
Twin
Pregnancy
Venous thromboembolism
Issue Date: Jun-2013
Publisher: Pergamon-Elsevier Science Ltd
Journal Title: Thrombosis Research
Volume: 131
Issue: 6
Start Page: 493
End Page: 496
Publisher DOI: 10.1016/j.thromres.2013.04.029
PMID: 23726968
Abstract: Introduction: The differences in the D-dimer rise between women with singleton and multifetal pregnancies have not been studied extensively. Materials and Methods: D-Dimer levels were determined in 1089 blood specimens from 1089 women in various stages of pregnancy, including 977 and 112 women with singleton and multifetal pregnancies, respectively. None of the 1089 women developed hypertension or clinical venous thromboembolism during pregnancy or in the postpartum period. Results: The D-dimer levels were significantly and positively correlated with gestational week at examination in women with singleton or multifetal pregnancies. The D-dimer levels (mu g/ml, mean +/- SD [number of specimens]) determined at the 1st trimester did not differ significantly (0.81 +/- 0.82 [102] for singleton vs. 1.20 +/- 0.77 [7] for multifetal), but those at the 2nd (1.61 +/- 1.45 [216] vs. 2.62 +/- 2.26 [59]) and 3rd (2.37 +/- 2.22 [659] vs. 4.02 +/- 2.14 [46]) trimesters were significantly higher in women with multifetal than singleton pregnancies. The 90th percentile value was 4.31 mu g/ml for 1089 specimens. A significantly greater number of women exceeded 4.31 mu g/ml during the 2nd (16.9% vs. 5.6%, P = 0.0043) and 3rd (34.8% vs. 10.6%, P < 0.0001) trimesters among those with multifetal than with singleton pregnancies. Conclusions: The degree of D-dimer rise in pregnancy was greater in women with multifetal than with singleton pregnancies. (C) 2013 Elsevier Ltd. All rights reserved.
Type: article (author version)
URI: http://hdl.handle.net/2115/53075
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 水上 尚典

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