| Title: | Impaired integrity of the brain parenchyma in non-geriatric patients with major depressive disorder revealed by diffusion tensor imaging |
| Authors: | Tha, Khin K. Browse this author →KAKEN DB |
| Terae, Satoshi Browse this author →KAKEN DB |
| Nakagawa, Shin Browse this author →KAKEN DB |
| Inoue, Takeshi Browse this author →KAKEN DB |
| Kitagawa, Nobuki Browse this author →KAKEN DB |
| Kako, Yuki Browse this author →KAKEN DB |
| Nakato, Yasuya Browse this author |
| Popy, Kawser Akter Browse this author |
| Fujima, Noriyuki Browse this author |
| Zaitsu, Yuri Browse this author |
| Yoshida, Daisuke Browse this author |
| Ito, Yoichi M. Browse this author |
| Miyamoto, Tamaki Browse this author →KAKEN DB |
| Koyama, Tsukasa Browse this author →KAKEN DB |
| Shirato, Hiroki Browse this author →KAKEN DB |
| Keywords: | Fractional anisotropy |
| Mean diffusivity |
| Voxel-based analysis |
| Histogram |
| Issue Date: | 30-Jun-2013 |
| Publisher: | Elsevier Ireland Ltd |
| Journal Title: | Psychiatry Research : Neuroimaging |
| Volume: | 212 |
| Issue: | 3 |
| Start Page: | 208 |
| End Page: | 215 |
| Publisher DOI: | 10.1016/j.pscychresns.2012.07.004 |
| PMID: | 23149032 |
| Abstract: | Diffusion tensor imaging (DTI) is considered to be able to non-invasively quantify white matter integrity. This study aimed to use DTI to evaluate white matter integrity in non-geriatric patients with major depressive disorder (MDD) who were free of antidepressant medication. DTI was performed on 19 non-geriatric patients with MDD, free of antidepressant medication, and 19 age-matched healthy subjects. Voxel-based and histogram analyses were used to compare fractional anisotropy (FA) and mean diffusivity (MD) values between the two groups, using two-sample t tests. The abnormal DTI indices, if any, were tested for correlation with disease duration and severity, using Pearson product-moment correlation analysis. Voxel-based analysis showed clusters with FA decrease at the bilateral frontal white matter, anterior limbs of internal capsule, cerebellum, left putamen and right thalamus of the patients. Histogram analysis revealed lower peak position of FA histograms in the patients. FA values of the abnormal clusters and peak positions of FA histograms of the patients exhibited moderate correlation with disease duration and severity. These results suggest the implication of frontal-subcortical circuits and cerebellum in MDD, and the potential utility of FA in evaluation of brain parenchymal integrity. (C) 2012 Elsevier Ireland Ltd. All rights reserved. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/53150 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
