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Impaired integrity of the brain parenchyma in non-geriatric patients with major depressive disorder revealed by diffusion tensor imaging

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Title: Impaired integrity of the brain parenchyma in non-geriatric patients with major depressive disorder revealed by diffusion tensor imaging
Authors: Tha, Khin K. Browse this author →KAKEN DB
Terae, Satoshi Browse this author →KAKEN DB
Nakagawa, Shin Browse this author →KAKEN DB
Inoue, Takeshi Browse this author →KAKEN DB
Kitagawa, Nobuki Browse this author →KAKEN DB
Kako, Yuki Browse this author →KAKEN DB
Nakato, Yasuya Browse this author
Popy, Kawser Akter Browse this author
Fujima, Noriyuki Browse this author
Zaitsu, Yuri Browse this author
Yoshida, Daisuke Browse this author
Ito, Yoichi M. Browse this author
Miyamoto, Tamaki Browse this author →KAKEN DB
Koyama, Tsukasa Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Keywords: Fractional anisotropy
Mean diffusivity
Voxel-based analysis
Issue Date: 30-Jun-2013
Publisher: Elsevier Ireland Ltd
Journal Title: Psychiatry Research : Neuroimaging
Volume: 212
Issue: 3
Start Page: 208
End Page: 215
Publisher DOI: 10.1016/j.pscychresns.2012.07.004
PMID: 23149032
Abstract: Diffusion tensor imaging (DTI) is considered to be able to non-invasively quantify white matter integrity. This study aimed to use DTI to evaluate white matter integrity in non-geriatric patients with major depressive disorder (MDD) who were free of antidepressant medication. DTI was performed on 19 non-geriatric patients with MDD, free of antidepressant medication, and 19 age-matched healthy subjects. Voxel-based and histogram analyses were used to compare fractional anisotropy (FA) and mean diffusivity (MD) values between the two groups, using two-sample t tests. The abnormal DTI indices, if any, were tested for correlation with disease duration and severity, using Pearson product-moment correlation analysis. Voxel-based analysis showed clusters with FA decrease at the bilateral frontal white matter, anterior limbs of internal capsule, cerebellum, left putamen and right thalamus of the patients. Histogram analysis revealed lower peak position of FA histograms in the patients. FA values of the abnormal clusters and peak positions of FA histograms of the patients exhibited moderate correlation with disease duration and severity. These results suggest the implication of frontal-subcortical circuits and cerebellum in MDD, and the potential utility of FA in evaluation of brain parenchymal integrity. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: Khin Khin Tha

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