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Ca2+-binding properties and regulatory roles of lobster troponin C sites II and IV

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Title: Ca2+-binding properties and regulatory roles of lobster troponin C sites II and IV
Authors: Tanaka, Hiroyuki Browse this author →KAKEN DB
Takahashi, Hiroki Browse this author →KAKEN DB
Ojima, Takao Browse this author →KAKEN DB
Keywords: Troponin
Issue Date: 19-Aug-2013
Publisher: Elsevier science bv
Journal Title: Febs letters
Volume: 587
Issue: 16
Start Page: 2612
End Page: 2616
Publisher DOI: 10.1016/j.febslet.2013.06.042
PMID: 23831063
Abstract: Invertebrate troponin C typically contains Ca2+-specific binding sites, sites II and IV, in the N- and C-terminal domains, respectively. To investigate the roles of these sites for Ca2+-dependent regulation of muscle contraction, we generated lobster troponin C mutants, and analyzed their Ca2+-binding properties and regulatory effects on actomyosin-tropomyosin Mg-ATPase activity. The results suggest that Ca2+ binding to site IV is responsible for regulation at relatively low Ca2+ concentrations, while site II has an essential role in full activation at higher Ca2+ concentrations. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Type: article (author version)
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 田中 啓之

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