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Recovery of leptospires from miniature pigs experimentally infected with Leptospira interrogans serovar Manilae strain UP-MMC under immunosuppressive conditions by dexamethasone.
Title: | Recovery of leptospires from miniature pigs experimentally infected with Leptospira interrogans serovar Manilae strain UP-MMC under immunosuppressive conditions by dexamethasone. |
Authors: | Sakoda, Yoshihiro Browse this author →KAKEN DB | Naito, Michiko Browse this author | Ito, Mutsumi Browse this author | Ito, Yuki Browse this author | Isoda, Norikazu Browse this author | Tanaka, Tomohisa Browse this author | Umemura, Takashi Browse this author →KAKEN DB | Kida, Hiroshi Browse this author →KAKEN DB |
Keywords: | experimental infection | immunosuppression | leptospira | swine |
Issue Date: | 4-Aug-2012 |
Publisher: | the Japanese Society of Veterinary Science |
Journal Title: | Journal of Veterinary Medical Science |
Volume: | 74 |
Issue: | 7 |
Start Page: | 955 |
End Page: | 958 |
Publisher DOI: | 10.1292/jvms.11-0537 |
PMID: | 22446397 |
Abstract: | Leptospira interrogans serovar Manilae strain UP-MMC was inoculated into miniature pigs to assess its pathogenicity. Leptospires were recovered from the whole blood, kidneys, and livers in the acute phase without showing any clinical signs. Under immunosuppressive conditions by dexamethasone, leptospires were recovered from the kidneys and their genes were detected from the urine in the chronic phase. These results indicate that leptospires persisted in the kidneys until the chronic phase, and excretion of leptospires in the urine was enhanced under immunosuppressive conditions, resulting in horizontal transmission among pigs on farms. |
Type: | article |
URI: | http://hdl.handle.net/2115/53282 |
Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 喜田 宏
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