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Recovery of leptospires from miniature pigs experimentally infected with Leptospira interrogans serovar Manilae strain UP-MMC under immunosuppressive conditions by dexamethasone.

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Title: Recovery of leptospires from miniature pigs experimentally infected with Leptospira interrogans serovar Manilae strain UP-MMC under immunosuppressive conditions by dexamethasone.
Authors: Sakoda, Yoshihiro Browse this author →KAKEN DB
Naito, Michiko Browse this author
Ito, Mutsumi Browse this author
Ito, Yuki Browse this author
Isoda, Norikazu Browse this author
Tanaka, Tomohisa Browse this author
Umemura, Takashi Browse this author →KAKEN DB
Kida, Hiroshi Browse this author →KAKEN DB
Keywords: experimental infection
immunosuppression
leptospira
swine
Issue Date: 4-Aug-2012
Publisher: the Japanese Society of Veterinary Science
Journal Title: Journal of Veterinary Medical Science
Volume: 74
Issue: 7
Start Page: 955
End Page: 958
Publisher DOI: 10.1292/jvms.11-0537
PMID: 22446397
Abstract: Leptospira interrogans serovar Manilae strain UP-MMC was inoculated into miniature pigs to assess its pathogenicity. Leptospires were recovered from the whole blood, kidneys, and livers in the acute phase without showing any clinical signs. Under immunosuppressive conditions by dexamethasone, leptospires were recovered from the kidneys and their genes were detected from the urine in the chronic phase. These results indicate that leptospires persisted in the kidneys until the chronic phase, and excretion of leptospires in the urine was enhanced under immunosuppressive conditions, resulting in horizontal transmission among pigs on farms.
Type: article
URI: http://hdl.handle.net/2115/53282
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 喜田 宏

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