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Medial vascular calcification: a new concept challenging the classical paradigm of dystrophic calcification

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Title: Medial vascular calcification: a new concept challenging the classical paradigm of dystrophic calcification
Authors: Hasegawa, Tomoka Browse this author
Sasaki, Muneteru Browse this author
Liu, Zhusheng Browse this author
Yamada, Tamaki Browse this author
Yamamoto, Tomomaya Browse this author
Hongo, Hiromi Browse this author
Suzuki, Reiko Browse this author →KAKEN DB
Miyamoto, Yukina Browse this author
Yamamoto, Tsuneyuki Browse this author →KAKEN DB
Freitas, Paulo H. L. de Browse this author
Li, Minqi Browse this author →KAKEN DB
Amizuka, Norio Browse this author →KAKEN DB
Keywords: klotho
medial calcification
vascular smooth muscle cell
matrix vesicles
Issue Date: Sep-2013
Publisher: 北海道歯学会
Journal Title: 北海道歯学雑誌
Volume: 34
Issue: 1
Start Page: 2
End Page: 10
Abstract: Klotho deficient (kl/kl) mice are well known to develop hyperphosphatemia and resultant Möncheberg’s vascular sclerosis, which consists of elongated or fragmented elastic lamellae and abundant collagen fibrils inside the vessels. Instead of normal vascular smooth muscle cells (VSMCs), the tunica media of the kl/kl aorta has cells rich with abundant endoplasmic reticulum and Golgi apparatus, somewhat resembling osteoblasts. There were many matrix vesicle-like structures and calcifying nodules in the vicinity of these osteoblast-like cells in kl/kl aorta. The calcifying nodules seem to trigger calcification in the elastic lamellae, without promoting it in the collagen fibrils inside the kl/kl aorta. Also, mineral deposition was observed within the intravascular amorphous organic component, suggesting dystrophic calcification. Thus, two possible pathways for vascular calcification exist: one mediated by matrix vesicle-like structures, and another taking place after the deposition of calcium phosphates in the amorphous organic component. Compared to the latter, which consists of the classical view of intravascular calcification, the former appears to mimic osteoblastic mineralization in bone, and could be the result of trans-differentiation of VSMCs into osteoblastic cells. In this work, we will review our current findings on the process of medial vascular calcification found in kl/kl mice.
Type: article
Appears in Collections:北海道歯学雑誌 = Hokkaido Journal of Dental Science > 第34巻 第1号

Submitter: 長谷川 智香

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