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Methyl Caffeate as an α-Glucosidase Inhibitor from Solanum torvum Fruits and the Activity of Related Compounds

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Title: Methyl Caffeate as an α-Glucosidase Inhibitor from Solanum torvum Fruits and the Activity of Related Compounds
Authors: TAKAHASHI, Keisuke Browse this author
YOSHIOKA, Yasuyuki Browse this author
KATO, Eisuke Browse this author →KAKEN DB
KATSUKI, Shigeki Browse this author
IIDA, Osamu Browse this author
HOSOKAWA, Keizo Browse this author
KAWABATA, Jun Browse this author →KAKEN DB
Keywords: Solanum torvum
α-glucosidase inhibitor
methyl caffeate
Issue Date: Apr-2010
Publisher: 日本農芸化学会
Journal Title: Bioscience, Biotechnology, and Biochemistry
Volume: 74
Issue: 4
Start Page: 741
End Page: 745
Publisher DOI: 10.1271/bbb.90789
PMID: 20378981
Abstract: In screening experiments for rat intestinal α-glucosidase (sucrase and maltase) inhibitors in 325 plants cultivated in Japan’s southern island, of Tanegashima, marked inhibition against both sucrase and maltase was found in the extract of the fruit of Solanum torvum. Enzyme-assay guided fractionation of the extract led to the isolation of methyl caffeate (1) as a rat intestinal sucrase and maltase inhibitor. We examined 13 caffeoyl derivatives for sucrase- and maltase-inhibitory activities. The results showed that methyl caffeate (1) had a most favorable structure for both sucrase and maltase inhibition, except for a higher activity of methyl 3,4,5-trihydroxycinnamate (14) against sucrase. Its moderate inhibitory action against α-glucosidase provides a prospect for antidiabetic usage of S. torvum fruit.
Type: article
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 英介

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