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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >
Methyl Caffeate as an α-Glucosidase Inhibitor from Solanum torvum Fruits and the Activity of Related Compounds
| Title: | Methyl Caffeate as an α-Glucosidase Inhibitor from Solanum torvum Fruits and the Activity of Related Compounds |
| Authors: | TAKAHASHI, Keisuke Browse this author | | YOSHIOKA, Yasuyuki Browse this author | | KATO, Eisuke Browse this author →KAKEN DB | | KATSUKI, Shigeki Browse this author | | IIDA, Osamu Browse this author | | HOSOKAWA, Keizo Browse this author | | KAWABATA, Jun Browse this author →KAKEN DB |
| Keywords: | Solanum torvum | | α-glucosidase inhibitor | | methyl caffeate | | Tanegashima |
| Issue Date: | Apr-2010 |
| Publisher: | 日本農芸化学会 |
| Journal Title: | Bioscience, Biotechnology, and Biochemistry |
| Volume: | 74 |
| Issue: | 4 |
| Start Page: | 741 |
| End Page: | 745 |
| Publisher DOI: | 10.1271/bbb.90789 |
| PMID: | 20378981 |
| Abstract: | In screening experiments for rat intestinal α-glucosidase (sucrase and maltase) inhibitors in 325 plants cultivated in Japan’s southern island, of Tanegashima, marked inhibition against both sucrase and maltase was found in the extract of the fruit of Solanum torvum. Enzyme-assay guided fractionation of the extract led to the isolation of methyl caffeate (1) as a rat intestinal sucrase and maltase inhibitor. We examined 13 caffeoyl derivatives for sucrase- and maltase-inhibitory activities. The results showed that methyl caffeate (1) had a most favorable structure for both sucrase and maltase inhibition, except for a higher activity of methyl 3,4,5-trihydroxycinnamate (14) against sucrase. Its moderate inhibitory action against α-glucosidase provides a prospect for antidiabetic usage of S. torvum fruit. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/53430 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 加藤 英介
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