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Plasma Aldosterone Concentration and Plasma Renin Activity Decrease during the Third Trimester in Women with Twin Pregnancies

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/53469

Title: Plasma Aldosterone Concentration and Plasma Renin Activity Decrease during the Third Trimester in Women with Twin Pregnancies
Authors: Koyama, Takahiro Browse this author
Yamada, Takashi Browse this author →KAKEN DB
Furuta, Itsuko Browse this author →KAKEN DB
Morikawa, Mamoru Browse this author →KAKEN DB
Yamada, Takahiro Browse this author →KAKEN DB
Minakami, Hisanori Browse this author →KAKEN DB
Keywords: aldosterone
hypertension
preeclampsia
renin activity
twin pregnancy
Issue Date: Nov-2012
Publisher: Informa Healthcare
Journal Title: Hypertension in Pregnancy
Volume: 31
Issue: 4
Start Page: 419
End Page: 426
Publisher DOI: 10.3109/10641955.2012.690057
PMID: 22676457
Abstract: Objective: Changes in the plasma aldosterone concentration (PAC) and the plasma renin activity (PRA) have not been extensively studied in women with twin pregnancies. Methods: The PAC and PRA levels were determined during the second and third trime-sters and on postpartum day 3 in 14 normotensive women with twin pregnancies and 80 normotensive and 7 preeclamptic women with singleton pregnancies. Results: In women with twin pregnancies, elevated PAC and PRA levels (598 ± 248 pg/mL and 10.0 ±4.7 ng/ mL/h, respectively) in the second trimester decreased significantly during the third trimester (to 396 ± 210 pg/mL and 3.5 ± 2.9 ng/mL/h, respectively), whereas the corre-sponding PAC increased significantly (from 421 ± 207 to 667 ± 371 pg/mL) and the PRA did not change significantly (from 7.3 ± 3.4 to 6.9 ± 4.2 ng/mL/h) in women with normal singleton pregnancies. These changes in the PAC and PRA levels in women with twin pregnancies resembled those in hypertensive women with singleton pregnancies. Conclusions: In women with twin pregnancies, both the PAC and PRA levels were significantly enhanced during the second trimester, whereas those in the third trimester were significantly reduced compared with those in women with normal singleton pregnancies.
Type: article (author version)
URI: http://hdl.handle.net/2115/53469
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 水上 尚典

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