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Plasma Aldosterone Concentration and Plasma Renin Activity Decrease during the Third Trimester in Women with Twin Pregnancies
Title: | Plasma Aldosterone Concentration and Plasma Renin Activity Decrease during the Third Trimester in Women with Twin Pregnancies |
Authors: | Koyama, Takahiro Browse this author | Yamada, Takashi Browse this author →KAKEN DB | Furuta, Itsuko Browse this author →KAKEN DB | Morikawa, Mamoru Browse this author →KAKEN DB | Yamada, Takahiro Browse this author →KAKEN DB | Minakami, Hisanori Browse this author →KAKEN DB |
Keywords: | aldosterone | hypertension | preeclampsia | renin activity | twin pregnancy |
Issue Date: | Nov-2012 |
Publisher: | Informa Healthcare |
Journal Title: | Hypertension in Pregnancy |
Volume: | 31 |
Issue: | 4 |
Start Page: | 419 |
End Page: | 426 |
Publisher DOI: | 10.3109/10641955.2012.690057 |
PMID: | 22676457 |
Abstract: | Objective: Changes in the plasma aldosterone concentration (PAC) and the plasma renin activity (PRA) have not been extensively studied in women with twin pregnancies. Methods: The PAC and PRA levels were determined during the second and third trime-sters and on postpartum day 3 in 14 normotensive women with twin pregnancies and 80 normotensive and 7 preeclamptic women with singleton pregnancies. Results: In women with twin pregnancies, elevated PAC and PRA levels (598 ± 248 pg/mL and 10.0 ±4.7 ng/ mL/h, respectively) in the second trimester decreased significantly during the third trimester (to 396 ± 210 pg/mL and 3.5 ± 2.9 ng/mL/h, respectively), whereas the corre-sponding PAC increased significantly (from 421 ± 207 to 667 ± 371 pg/mL) and the PRA did not change significantly (from 7.3 ± 3.4 to 6.9 ± 4.2 ng/mL/h) in women with normal singleton pregnancies. These changes in the PAC and PRA levels in women with twin pregnancies resembled those in hypertensive women with singleton pregnancies. Conclusions: In women with twin pregnancies, both the PAC and PRA levels were significantly enhanced during the second trimester, whereas those in the third trimester were significantly reduced compared with those in women with normal singleton pregnancies. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/53469 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 水上 尚典
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