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Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1 alpha-MUC1 pathway
| Title: | Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1 alpha-MUC1 pathway |
| Authors: | Goudarzi, Houman Browse this author | | Iizasa, Hisashi Browse this author →KAKEN DB | | Furuhashi, Masako Browse this author | | Nakazawa, Seitaro Browse this author | | Nakane, Rie Browse this author | | Liang, Shanshan Browse this author | | Hida, Yasuhiro Browse this author →KAKEN DB | | Yanagihara, Kazuyoshi Browse this author | | Kubo, Takanori Browse this author | | Nakagawa, Koji Browse this author →KAKEN DB | | Kobayashi, Masanobu Browse this author | | Irimura, Tatsuro Browse this author | | Hamada, Jun-ichi Browse this author →KAKEN DB |
| Keywords: | Mesothelioma | | Hypoxia | | HIF | | MUC1 | | Motility | | Invasiveness |
| Issue Date: | 1-Oct-2013 |
| Publisher: | Elsevier ireland ltd |
| Journal Title: | Cancer letters |
| Volume: | 339 |
| Issue: | 1 |
| Start Page: | 82 |
| End Page: | 92 |
| Publisher DOI: | 10.1016/j.canlet.2013.07.020 |
| PMID: | 23879962 |
| Abstract: | In this study, we examined the effects of hypoxia on the malignancy of human malignant pleural mesothelioma (MPM) cell lines, and found (I) hypoxia enhanced motility and invasiveness of human malignant pleural mesothelioma (MPM) cells; (2) this phenomenon resulted from increased expression of sialylated MUC1 through the activation of HIF-1 pathway; (3) two HIF-binding sites located in the promoter region of MUC1 were important for MUC1 transactivation under hypoxia. These findings are useful for better understanding molecular mechanisms of aggressive behavior of MPM cells and for targeting them in the clinical therapies for MPM patients. |
| Relation: | http://www.sciencedirect.com/science/journal/03043835/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/53474 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 浜田 淳一
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