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Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1 alpha-MUC1 pathway

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Title: Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1 alpha-MUC1 pathway
Authors: Goudarzi, Houman Browse this author
Iizasa, Hisashi Browse this author →KAKEN DB
Furuhashi, Masako Browse this author
Nakazawa, Seitaro Browse this author
Nakane, Rie Browse this author
Liang, Shanshan Browse this author
Hida, Yasuhiro Browse this author →KAKEN DB
Yanagihara, Kazuyoshi Browse this author
Kubo, Takanori Browse this author
Nakagawa, Koji Browse this author →KAKEN DB
Kobayashi, Masanobu Browse this author
Irimura, Tatsuro Browse this author
Hamada, Jun-ichi Browse this author →KAKEN DB
Keywords: Mesothelioma
Hypoxia
HIF
MUC1
Motility
Invasiveness
Issue Date: 1-Oct-2013
Publisher: Elsevier ireland ltd
Journal Title: Cancer letters
Volume: 339
Issue: 1
Start Page: 82
End Page: 92
Publisher DOI: 10.1016/j.canlet.2013.07.020
PMID: 23879962
Abstract: In this study, we examined the effects of hypoxia on the malignancy of human malignant pleural mesothelioma (MPM) cell lines, and found (I) hypoxia enhanced motility and invasiveness of human malignant pleural mesothelioma (MPM) cells; (2) this phenomenon resulted from increased expression of sialylated MUC1 through the activation of HIF-1 pathway; (3) two HIF-binding sites located in the promoter region of MUC1 were important for MUC1 transactivation under hypoxia. These findings are useful for better understanding molecular mechanisms of aggressive behavior of MPM cells and for targeting them in the clinical therapies for MPM patients.
Relation: http://www.sciencedirect.com/science/journal/03043835/
Type: article (author version)
URI: http://hdl.handle.net/2115/53474
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 浜田 淳一

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