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Reciprocal Expression of Enteric Antimicrobial Proteins in Intestinal Graft-Versus-Host Disease

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Title: Reciprocal Expression of Enteric Antimicrobial Proteins in Intestinal Graft-Versus-Host Disease
Authors: Eriguchi, Yoshihiro Browse this author
Uryu, Hidetaka Browse this author
Nakamura, Kiminori Browse this author
Shimoji, Sonoko Browse this author
Takashima, Shuichiro Browse this author
Iwasaki, Hiromi Browse this author
Miyamoto, Toshihiro Browse this author
Shimono, Nobuyuki Browse this author
Hashimoto, Daigo Browse this author
Akashi, Koichi Browse this author
Ayabe, Tokiyoshi Browse this author
Teshima, Takanori Browse this author →KAKEN DB
Keywords: Hematopoietic stem cell transplantation
Graft-versus-host disease
Regenerating islet-derived III
Defensins
Toll-like receptors
Issue Date: Oct-2013
Publisher: Elsevier science inc
Journal Title: Biology of blood and marrow transplantation
Volume: 19
Issue: 10
Start Page: 1525
End Page: 1529
Publisher DOI: 10.1016/j.bbmt.2013.07.027
PMID: 23927965
Abstract: We recently demonstrated that expression of alpha-defensins, the major antimicrobial peptides produced by Paneth cells, was severely suppressed in mice with graft-versus-host disease (GVHD). In this study, we found that antibacterial lectin, regenerating islet-derived III gamma (RegIII gamma) was upregulated in villous enterocytes, thus demonstrating the reciprocal control of enteric antimicrobial proteins in GVHD. Upregulation of RegIII gamma was mediated by a mechanism independent upon radiation-induced intestinal tract damage. MyD88-mediated signaling in intestinal epithelium was required for RegIII gamma upregulation in GVHD and antibiotic therapy downregulated RegIII gamma expression. These results suggest that MyD88-mediated sensing of the intestinal microbes disregulated in GVHD induces RegIII gamma upregulation in GVHD and argue a role for RegIII gamma in the pathogenesis of GVHD. (C) 2013 American Society for Blood and Marrow Transplantation.
Type: article (author version)
URI: http://hdl.handle.net/2115/53606
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 豊嶋 崇徳

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