| Title: | Reciprocal Expression of Enteric Antimicrobial Proteins in Intestinal Graft-Versus-Host Disease |
| Authors: | Eriguchi, Yoshihiro Browse this author |
| Uryu, Hidetaka Browse this author |
| Nakamura, Kiminori Browse this author |
| Shimoji, Sonoko Browse this author |
| Takashima, Shuichiro Browse this author |
| Iwasaki, Hiromi Browse this author |
| Miyamoto, Toshihiro Browse this author |
| Shimono, Nobuyuki Browse this author |
| Hashimoto, Daigo Browse this author |
| Akashi, Koichi Browse this author |
| Ayabe, Tokiyoshi Browse this author |
| Teshima, Takanori Browse this author →KAKEN DB |
| Keywords: | Hematopoietic stem cell transplantation |
| Graft-versus-host disease |
| Regenerating islet-derived III |
| Defensins |
| Toll-like receptors |
| Issue Date: | Oct-2013 |
| Publisher: | Elsevier science inc |
| Journal Title: | Biology of blood and marrow transplantation |
| Volume: | 19 |
| Issue: | 10 |
| Start Page: | 1525 |
| End Page: | 1529 |
| Publisher DOI: | 10.1016/j.bbmt.2013.07.027 |
| PMID: | 23927965 |
| Abstract: | We recently demonstrated that expression of alpha-defensins, the major antimicrobial peptides produced by Paneth cells, was severely suppressed in mice with graft-versus-host disease (GVHD). In this study, we found that antibacterial lectin, regenerating islet-derived III gamma (RegIII gamma) was upregulated in villous enterocytes, thus demonstrating the reciprocal control of enteric antimicrobial proteins in GVHD. Upregulation of RegIII gamma was mediated by a mechanism independent upon radiation-induced intestinal tract damage. MyD88-mediated signaling in intestinal epithelium was required for RegIII gamma upregulation in GVHD and antibiotic therapy downregulated RegIII gamma expression. These results suggest that MyD88-mediated sensing of the intestinal microbes disregulated in GVHD induces RegIII gamma upregulation in GVHD and argue a role for RegIII gamma in the pathogenesis of GVHD. (C) 2013 American Society for Blood and Marrow Transplantation. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/53606 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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