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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
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The nucleoprotein is responsible for intracerebral pathogenicity of A/duck/Mongolia/47/2001 (H7N1) in chicks
| Title: | The nucleoprotein is responsible for intracerebral pathogenicity of A/duck/Mongolia/47/2001 (H7N1) in chicks |
| Authors: | Isoda, Norikazu Browse this author | | Tsuda, Yoshimi Browse this author | | Asakura, Shingo Browse this author | | Okamatsu, Masatoshi Browse this author →KAKEN DB | | Sakoda, Yoshihiro Browse this author →KAKEN DB | | Kida, Hiroshi Browse this author →KAKEN DB |
| Keywords: | avian influenza | | intracerebral pathogenicity | | nucleoprotein |
| Issue Date: | Dec-2012 |
| Publisher: | Springer Vienna |
| Journal Title: | Archives of Virology |
| Volume: | 157 |
| Issue: | 12 |
| Start Page: | 2257 |
| End Page: | 2264 |
| Publisher DOI: | 10.1007/s00705-012-1415-7 |
| PMID: | 22833102 |
| Abstract: | Avian influenza viruses, A/duck/Mongolia/47/2001 (H7N1) (47/01) and A/duck/Mongolia/867/2002 (H7N1) (867/02), were defined as low pathogenic avian influenza viruses (LPAIVs) by intravenous pathogenicity test in chickens. On the other hand, the intracerebral pathogenicity indices of 47/01 and 867/02 were 1.30 and 0.00, respectively. A series of reassortant viruses were generated between 47/01 and 867/02, and their intracerebral pathogenicity was compared in one-day-old chicks to identify the protein(s) responsible for the intracerebral pathogenicity of 47/01. The results indicate that the amino acid positions at 50 and 98 of the nucleoprotein are related to the pathogenicity of 47/01 in chicks by intracerebral inoculation. A significant association was found between mortality of the chicks inoculated intracerebrally with 47/01 and virus replication in the lungs and/or brains. These results indicate that the NP of avian influenza viruses may be responsible for intracerebral pathogenicity in hosts. |
| Rights: | The original publication is available at www.springerlink.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/54006 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 喜田 宏
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