HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >

The nucleoprotein is responsible for intracerebral pathogenicity of A/duck/Mongolia/47/2001 (H7N1) in chicks

Files in This Item:
AoV157-12_2257-2264.pdf438.71 kBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/54006

Title: The nucleoprotein is responsible for intracerebral pathogenicity of A/duck/Mongolia/47/2001 (H7N1) in chicks
Authors: Isoda, Norikazu Browse this author
Tsuda, Yoshimi Browse this author
Asakura, Shingo Browse this author
Okamatsu, Masatoshi Browse this author →KAKEN DB
Sakoda, Yoshihiro Browse this author →KAKEN DB
Kida, Hiroshi Browse this author →KAKEN DB
Keywords: avian influenza
intracerebral pathogenicity
nucleoprotein
Issue Date: Dec-2012
Publisher: Springer Vienna
Journal Title: Archives of Virology
Volume: 157
Issue: 12
Start Page: 2257
End Page: 2264
Publisher DOI: 10.1007/s00705-012-1415-7
PMID: 22833102
Abstract: Avian influenza viruses, A/duck/Mongolia/47/2001 (H7N1) (47/01) and A/duck/Mongolia/867/2002 (H7N1) (867/02), were defined as low pathogenic avian influenza viruses (LPAIVs) by intravenous pathogenicity test in chickens. On the other hand, the intracerebral pathogenicity indices of 47/01 and 867/02 were 1.30 and 0.00, respectively. A series of reassortant viruses were generated between 47/01 and 867/02, and their intracerebral pathogenicity was compared in one-day-old chicks to identify the protein(s) responsible for the intracerebral pathogenicity of 47/01. The results indicate that the amino acid positions at 50 and 98 of the nucleoprotein are related to the pathogenicity of 47/01 in chicks by intracerebral inoculation. A significant association was found between mortality of the chicks inoculated intracerebrally with 47/01 and virus replication in the lungs and/or brains. These results indicate that the NP of avian influenza viruses may be responsible for intracerebral pathogenicity in hosts.
Rights: The original publication is available at www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/54006
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 喜田 宏

Export metadata:

OAI-PMH ( junii2 , jpcoar )

MathJax is now OFF:


 

Feedback - Hokkaido University