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Aspartame-induced apoptosis in PC12 cells

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Title: Aspartame-induced apoptosis in PC12 cells
Authors: Horio, Yukari Browse this author
Sun, Yongkun Browse this author
Liu, Chuang Browse this author
Saito, Takeshi Browse this author →KAKEN DB
Kurasaki, Masaaki Browse this author →KAKEN DB
Keywords: Aspartame
Cytochrome c
Issue Date: Jan-2014
Publisher: Elsevier, B.V.
Journal Title: Environmental Toxicology and Pharmacology
Volume: 37
Issue: 1
Start Page: 158
End Page: 165
Publisher DOI: 10.1016/j.etap.2013.11.021
PMID: 24355796
Abstract: Aspartame is an artificial sweetner added to many low-calorie foods. The safety of aspartame remains controversial even though there are many studies on its risks. In this study, to understand the physiological effects of trace amounts of artificial sweetners on cells, the effects of aspartame on apoptosis were investigated using a PC12 cell system. In addition, the mechanism of apoptosis induced by aspartame in PC12 cells and effects on apoptotic factors such as cytochrome c, apoptosis-inducing factor, and caspase family proteins were studied by Western blotting and RT-PCR. Aspartame-induced apoptosis in PC12 cells in a dose-dependent manner. In addition, aspartame exposure increased the expressions of caspases 8 and 9, and cytochrome c. These results indicate that aspartame induces apoptosis mainly via mitochondrial pathway involved in apoptosis due to oxigen toxicity.
Type: article (author version)
Appears in Collections:環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 藏崎 正明

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