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Differential potential for envelope glycoprotein-mediated steric shielding of host cell surface proteins among filoviruses

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Title: Differential potential for envelope glycoprotein-mediated steric shielding of host cell surface proteins among filoviruses
Authors: Noyori, Osamu Browse this author
Matsuno, Keita Browse this author
Kajihara, Masahiro Browse this author
Nakayama, Eri Browse this author
Igarashi, Manabu Browse this author
Kuroda, Makoto Browse this author
Isoda, Norikazu Browse this author
Yoshida, Reiko Browse this author
Takada, Ayato Browse this author →KAKEN DB
Keywords: Ebola virus
Marburg virus
Glycoprotein
Steric shielding
Integrin
MHC
Pathogenicity
Issue Date: Nov-2013
Publisher: Elsevier
Journal Title: Virology
Volume: 446
Issue: 1-2
Start Page: 152
End Page: 161
Publisher DOI: 10.1016/j.virol.2013.07.029
PMID: 24074577
Abstract: The viral envelope glycoprotein (GP) is thought to play important roles in the pathogenesis of filovirus infection. It is known that GP expressed on the cell surface forms a steric shield over host proteins such as major histocompatibility complex class I and integrin pi, which may result in the disorder of cell-to-cell contacts and/or inhibition of the immune response. However, it is not clarified whether this phenomenon contributes to the pathogenicity of filoviruses. In this study, we found that the steric shielding efficiency differed among filovirus strains and was correlated with the difference in their relative pathogenicities. While the highly glycosylated mucin-like region of GP was indispensable, the differential shielding efficiency did not necessarily depend on the primary structure of the mucin-like region, suggesting the importance of the overall properties (e.g., flexibility and stability) of the GP molecule for efficient shielding of host proteins. (C) 2013 Elsevier Inc. All rights reserved.
Type: article (author version)
URI: http://hdl.handle.net/2115/54100
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高田 礼人

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