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Differential potential for envelope glycoprotein-mediated steric shielding of host cell surface proteins among filoviruses

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タイトル: Differential potential for envelope glycoprotein-mediated steric shielding of host cell surface proteins among filoviruses
著者: Noyori, Osamu 著作を一覧する
Matsuno, Keita 著作を一覧する
Kajihara, Masahiro 著作を一覧する
Nakayama, Eri 著作を一覧する
Igarashi, Manabu 著作を一覧する
Kuroda, Makoto 著作を一覧する
Isoda, Norikazu 著作を一覧する
Yoshida, Reiko 著作を一覧する
Takada, Ayato 著作を一覧する
キーワード: Ebola virus
Marburg virus
Glycoprotein
Steric shielding
Integrin
MHC
Pathogenicity
発行日: 2013年11月
出版者: Elsevier
誌名: Virology
巻: 446
号: 1-2
開始ページ: 152
終了ページ: 161
出版社 DOI: 10.1016/j.virol.2013.07.029
抄録: The viral envelope glycoprotein (GP) is thought to play important roles in the pathogenesis of filovirus infection. It is known that GP expressed on the cell surface forms a steric shield over host proteins such as major histocompatibility complex class I and integrin pi, which may result in the disorder of cell-to-cell contacts and/or inhibition of the immune response. However, it is not clarified whether this phenomenon contributes to the pathogenicity of filoviruses. In this study, we found that the steric shielding efficiency differed among filovirus strains and was correlated with the difference in their relative pathogenicities. While the highly glycosylated mucin-like region of GP was indispensable, the differential shielding efficiency did not necessarily depend on the primary structure of the mucin-like region, suggesting the importance of the overall properties (e.g., flexibility and stability) of the GP molecule for efficient shielding of host proteins. (C) 2013 Elsevier Inc. All rights reserved.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/54100
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 高田 礼人

 

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