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First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies

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Title: First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies
Authors: Yamada, Takashi Browse this author →KAKEN DB
Morikawa, Mamoru Browse this author →KAKEN DB
Yamada, Takahiro Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Sengoku, Kazuo Browse this author
Endo, Toshiaki Browse this author
Saito, Tsuyoshi Browse this author
Cho, Kazutoshi Browse this author →KAKEN DB
Minakami, Hisanori Browse this author →KAKEN DB
Keywords: Abortion
Preterm birth
Serum folate
Issue Date: Jan-2013
Publisher: Springer-Verlag
Journal Title: Archives of Gynecology and Obstetrics
Volume: 287
Issue: 1
Start Page: 9
End Page: 14
Publisher DOI: 10.1007/s00404-012-2501-5
PMID: 22875049
Abstract: Objectives: To determine whether a low serum folate level during the first trimester predicts subsequent late abortion, preterm birth, or fetal growth restriction (FGR). Study design: A prospective cohort study involving 5,075 women whose serum folate levels were measured during the first trimester. The participants were informed of their serum folate levels. Results: The pregnancy duration, birthweight, rate of late abortion/preterm birth, and the rate of FGR did not differ significantly among four groups classified according to folate status. The mean serum folate levels did not differ among quartiles classified according to the gestational week at the time of delivery. Nineteen of the 20 women with folate deficiency gave birth at term to infants with a birthweight of 3,132 ± A 321 g; only one infant had FGR. Conclusion: Low serum folate levels during the first trimester were not associated with the risk of late abortion, preterm birth, or FGR.
Rights: © 2012 Springer. The final publication is available at
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山田 俊・水上 尚典

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