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Effects of KIR ligand incompatibility on clinical outcomes of umbilical cord blood transplantation without ATG for acute leukemia in complete remission

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Title: Effects of KIR ligand incompatibility on clinical outcomes of umbilical cord blood transplantation without ATG for acute leukemia in complete remission
Authors: Tanaka, J. Browse this author
Morishima, Y. Browse this author
Takahashi, Y. Browse this author
Yabe, T. Browse this author
Oba, K. Browse this author →KAKEN DB
Takahashi, S. Browse this author
Taniguchi, S. Browse this author
Ogawa, H. Browse this author
Onishi, Y. Browse this author
Miyamura, K. Browse this author
Kanamori, H. Browse this author
Aotsuka, N. Browse this author
Kato, K. Browse this author
Kato, S. Browse this author
Atsuta, Y. Browse this author
Kanda, Y. Browse this author
Keywords: CBT
GVHD
HVG
KIR
NK cell
Issue Date: Nov-2013
Publisher: Nature publishing group
Journal Title: Blood cancer journal
Volume: 3
Start Page: e164
Publisher DOI: 10.1038/bcj.2013.62
Abstract: To clarify the effect of killer cell immunoglobulin-like receptor (KIR) ligand incompatibility on outcomes of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) patients in complete remission after single cord blood transplantation (CBT), we assessed the outcomes of CBT registered in the Japan Society for Hematopoietic Cell Transplantation (JSHCT) database. A total of 643 acute leukemia (357 AML and 286 ALL) patient and donor pairs were categorized according to their KIR ligand incompatibility by determining whether or not they expressed HLA-C, Bw4 or A3/A11 by DNA typing. A total of 128 patient-donor pairs were KIR ligand-incompatible in the graft-versus-host (GVH) direction and 139 patient-donor pairs were incompatible in the host-versus-graft (HVG) direction. Univariate and multivariate analyses showed no significant differences between the KIR ligand-incompatible and compatible groups in the GVH direction for both AML and ALL patients of overall survival, disease-free survival, relapse incidence, non-relapse mortality and acute GVH disease. However, KIR incompatibility in the HVG direction ameliorated engraftment in ALL patients (hazard ratio 0.66, 95% confidence interval 0.47-0.91, P = 0.013). Therefore, there were no effects of KIR ligand incompatibility in the GVH direction on single CBT outcomes for acute leukemia patients without anti-thymocyte globulin use. However, it is necessary to pay attention to KIR incompatibility in the HVG direction for engraftment.
Rights: http://creativecommons.org/licenses/by/3.0/
Type: article
URI: http://hdl.handle.net/2115/54115
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大庭 幸治

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