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Osteocytes Regulate Primary Lymphoid Organs and Fat Metabolism

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Title: Osteocytes Regulate Primary Lymphoid Organs and Fat Metabolism
Authors: Sato, Mari Browse this author →KAKEN DB
Asada, Noboru Browse this author
Kawano, Yuko Browse this author
Wakahashi, Kanako Browse this author
Minagawa, Kentaro Browse this author →KAKEN DB
Kawano, Hiroki Browse this author
Sada, Akiko Browse this author
Ikeda, Kyoji Browse this author →KAKEN DB
Matsui, Toshimitsu Browse this author →KAKEN DB
Katayama, Yoshio Browse this author →KAKEN DB
Issue Date: 5-Nov-2013
Publisher: Cell press
Journal Title: Cell metabolism
Volume: 18
Issue: 5
Start Page: 749
End Page: 758
Publisher DOI: 10.1016/j.cmet.2013.09.014
PMID: 24140021
Abstract: Osteocytes act as mechanosensors to control local bone volume. However, their roles in the homeostasis of remote organs are largely unknown. We show that ablation of osteocytes in mice (osteocyte-less [OL] mice) leads to severe lymphopenia, due to lack of lymphoid-supporting stroma in both the bone marrow and thymus, and complete loss of white adipose tissues. These effects were reversed when osteocytes were replenished within the bone. In contrast, neither in vivo supply of T cell progenitors and humoral factors via shared circulation with a normal parabiotic partner nor ablation of specific hypothalamic nuclei rescued thymic atrophy and fat loss in OL mice. Furthermore, ablation of the hypothalamus in OL mice led to hepatic steatosis, which was rescued by parabiosis with normal mice. Our results define a role for osteocytes as critical regulators of lymphopoiesis and fat metabolism and suggest that bone acts as a central regulator of multiple organs.
Type: article (author version)
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐藤 真理

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