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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
Peer-reviewed Journal Articles, etc >
Osteocytes Regulate Primary Lymphoid Organs and Fat Metabolism
| Title: | Osteocytes Regulate Primary Lymphoid Organs and Fat Metabolism |
| Authors: | Sato, Mari Browse this author →KAKEN DB | | Asada, Noboru Browse this author | | Kawano, Yuko Browse this author | | Wakahashi, Kanako Browse this author | | Minagawa, Kentaro Browse this author →KAKEN DB | | Kawano, Hiroki Browse this author | | Sada, Akiko Browse this author | | Ikeda, Kyoji Browse this author →KAKEN DB | | Matsui, Toshimitsu Browse this author →KAKEN DB | | Katayama, Yoshio Browse this author →KAKEN DB |
| Issue Date: | 5-Nov-2013 |
| Publisher: | Cell press |
| Journal Title: | Cell metabolism |
| Volume: | 18 |
| Issue: | 5 |
| Start Page: | 749 |
| End Page: | 758 |
| Publisher DOI: | 10.1016/j.cmet.2013.09.014 |
| PMID: | 24140021 |
| Abstract: | Osteocytes act as mechanosensors to control local bone volume. However, their roles in the homeostasis of remote organs are largely unknown. We show that ablation of osteocytes in mice (osteocyte-less [OL] mice) leads to severe lymphopenia, due to lack of lymphoid-supporting stroma in both the bone marrow and thymus, and complete loss of white adipose tissues. These effects were reversed when osteocytes were replenished within the bone. In contrast, neither in vivo supply of T cell progenitors and humoral factors via shared circulation with a normal parabiotic partner nor ablation of specific hypothalamic nuclei rescued thymic atrophy and fat loss in OL mice. Furthermore, ablation of the hypothalamus in OL mice led to hepatic steatosis, which was rescued by parabiosis with normal mice. Our results define a role for osteocytes as critical regulators of lymphopoiesis and fat metabolism and suggest that bone acts as a central regulator of multiple organs. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/54128 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 佐藤 真理
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