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Osteocytes Regulate Primary Lymphoid Organs and Fat Metabolism

Cell Metab.18(5).final.pdf4.23 MBPDF見る/開く

タイトル: Osteocytes Regulate Primary Lymphoid Organs and Fat Metabolism
著者: Sato, Mari 著作を一覧する
Asada, Noboru 著作を一覧する
Kawano, Yuko 著作を一覧する
Wakahashi, Kanako 著作を一覧する
Minagawa, Kentaro 著作を一覧する
Kawano, Hiroki 著作を一覧する
Sada, Akiko 著作を一覧する
Ikeda, Kyoji 著作を一覧する
Matsui, Toshimitsu 著作を一覧する
Katayama, Yoshio 著作を一覧する
発行日: 2013年11月 5日
出版者: Cell press
誌名: Cell metabolism
巻: 18
号: 5
開始ページ: 749
終了ページ: 758
出版社 DOI: 10.1016/j.cmet.2013.09.014
抄録: Osteocytes act as mechanosensors to control local bone volume. However, their roles in the homeostasis of remote organs are largely unknown. We show that ablation of osteocytes in mice (osteocyte-less [OL] mice) leads to severe lymphopenia, due to lack of lymphoid-supporting stroma in both the bone marrow and thymus, and complete loss of white adipose tissues. These effects were reversed when osteocytes were replenished within the bone. In contrast, neither in vivo supply of T cell progenitors and humoral factors via shared circulation with a normal parabiotic partner nor ablation of specific hypothalamic nuclei rescued thymic atrophy and fat loss in OL mice. Furthermore, ablation of the hypothalamus in OL mice led to hepatic steatosis, which was rescued by parabiosis with normal mice. Our results define a role for osteocytes as critical regulators of lymphopoiesis and fat metabolism and suggest that bone acts as a central regulator of multiple organs.
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 佐藤 真理


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