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Anxiolytic-like effect of mirtazapine mediates its effect in the median raphe nucleus

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Title: Anxiolytic-like effect of mirtazapine mediates its effect in the median raphe nucleus
Authors: An, Yan Browse this author
Inoue, Takeshi Browse this author →KAKEN DB
Kitaichi, Yuji Browse this author
Izumi, Takeshi Browse this author →KAKEN DB
Nakagawa, Shin Browse this author →KAKEN DB
Song, Ning Browse this author
Chen, Chong Browse this author
Li, XiaoBai Browse this author
Koyama, Tsukasa Browse this author →KAKEN DB
Kusumi, Ichiro Browse this author →KAKEN DB
Keywords: Mirtazapine
Median raphe nucleus
Contextual fear condition
Issue Date: 15-Nov-2013
Publisher: Elsevier science bv
Journal Title: European journal of pharmacology
Volume: 720
Issue: 1-3
Start Page: 192
End Page: 197
Publisher DOI: 10.1016/j.ejphar.2013.09.078
PMID: 24436979
Abstract: Mirtazapine, a noradrenergic and specific serotonergic antidepressant (NaSSA), blocks the alpha(2)-adrenergic autoreceptors and heteroreceptors, which are responsible for controlling noradrenaline and 5-hydroxytryptamine (5-HT) release. Though preclinical and clinical studies have shown that mirtazapine exerts an anxiolytic action, its precise brain target sites remain unclear. In the present study, we investigated the brain area(s) in which mirtazapine exerts its anxiolytic-like effects on the expression of contextual conditioned freezing in rats. Mirtazapine (3 mu g/site) was directly injected into three brain structures, the median raphe nucleus (MRN), hippocampus and amygdala. Freezing behavior tests were carried out 10 min after injections. Our results showed that the intra-MRN injection of mirtazapine reduced freezing significantly, whereas injections into the hippocampus or the amygdala did not. In addition, the intra-MRN injection of mirtazapine did not affect locomotor activity. These results suggest that the anxiolytic-like effect of mirtazapine might be mediated by its action on the MRN. (C) 2013 Elsevier B.V. All rights reserved.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 井上 猛

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