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Transcription factor 8 activates R-Ras to regulate angiogenesis

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Title: Transcription factor 8 activates R-Ras to regulate angiogenesis
Authors: Inuzuka, Takayuki Browse this author
Tsuda, Masumi Browse this author →KAKEN DB
Kawaguchi, Hideaki Browse this author →KAKEN DB
Ohba, Yusuke Browse this author →KAKEN DB
Keywords: TCF8
Issue Date: 6-Feb-2009
Publisher: Elsevier
Journal Title: Biochemical and Biophysical Research Communications
Volume: 379
Issue: 2
Start Page: 510
End Page: 513
Publisher DOI: 10.1016/j.bbrc.2008.12.101
PMID: 19116136
Abstract: We have recently reported that transcription factor 8 (TCF8) negatively regulates pathological angiogenesis by regulating endothelial invasiveness by acting as a transcriptional attenuator of matrix metalloproteinase 1. TCF8 also modulates cell–matrix and cell–cell adhesion; however molecular mechanism of this TCF8 function remains obscure. Here, we provide evidence that TCF8 activates R-Ras, another class of angiogenic regulator, to suppress angiogenesis by a mechanism other than a transcriptional attenuator. Tube formation by human umbilical vein endothelial cells (HUVECs) facilitated by TCF8 suppression was significantly inhibited by the expression of onstitutive active mutant of R-Ras. When we examined the mRNA expression levels of R-Ras regulators, no significant changes were observed to explain the R-Ras activation by TCF8. Interestingly, we found that TCF8 bound to CalDAG-GEFIII, an R-Ras activator, in the cytosol, indicating that TCF8 emanates signaling for R-Ras activation from cytosol to regulate angiogenesis negatively.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大場 雄介

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