Suppression of Fas-mediated apoptosis via steric shielding by filovirus glycoproteins

Noyori, Osamu; Nakayama, Eri; Maruyama, Junki; Yoshida, Reiko; Takada, Ayato

doi:10.1016/j.bbrc.2013.11.018


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Suppression of Fas-mediated apoptosis via steric shielding by filovirus glycoproteins

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/54596

Title:	Suppression of Fas-mediated apoptosis via steric shielding by filovirus glycoproteins
Authors:	Noyori, Osamu Browse this author
	Nakayama, Eri Browse this author
	Maruyama, Junki Browse this author
	Yoshida, Reiko Browse this author
	Takada, Ayato Browse this author →KAKEN DB
Keywords:	Filovirus
	Glycoprotein
	Steric shielding
	Apoptosis
	Fas
Issue Date:	29-Nov-2013
Publisher:	Elsevier
Journal Title:	Biochemical and Biophysical Research Communications
Volume:	441
Issue:	4
Start Page:	994
End Page:	998
Publisher DOI:	10.1016/j.bbrc.2013.11.018
PMID:	24239546
Abstract:	Apoptotic death of virus-infected cells is generally thought to be a defense mechanism to limit the spread of infectious virions by eliminating virus-producing cells in host animals. On the other hand, several viruses have been shown to have anti-apoptotic mechanisms to facilitate efficient viral replication and transmission. In this study, we found that the filovirus glycoprotein (GP) expressed on cell surfaces formed a steric shield over the Fas molecule and that GP-expressing cells showed resistance to cell death induced by a Fas agonistic antibody. These results suggest that filovirus GP-mediated steric shielding may interfere with the Fas-induced apoptotic signal transduction in infected cells and serve as an immune evasion mechanism for filoviruses. (C) 2013 Elsevier Inc. All rights reserved.
Type:	article (author version)
URI:	http://hdl.handle.net/2115/54596
Appears in Collections:	人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高田礼人

OAI-PMH ( junii2 , jpcoar_1.0 )

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