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Suppression of Fas-mediated apoptosis via steric shielding by filovirus glycoproteins

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Title: Suppression of Fas-mediated apoptosis via steric shielding by filovirus glycoproteins
Authors: Noyori, Osamu Browse this author
Nakayama, Eri Browse this author
Maruyama, Junki Browse this author
Yoshida, Reiko Browse this author
Takada, Ayato Browse this author →KAKEN DB
Keywords: Filovirus
Steric shielding
Issue Date: 29-Nov-2013
Publisher: Elsevier
Journal Title: Biochemical and Biophysical Research Communications
Volume: 441
Issue: 4
Start Page: 994
End Page: 998
Publisher DOI: 10.1016/j.bbrc.2013.11.018
PMID: 24239546
Abstract: Apoptotic death of virus-infected cells is generally thought to be a defense mechanism to limit the spread of infectious virions by eliminating virus-producing cells in host animals. On the other hand, several viruses have been shown to have anti-apoptotic mechanisms to facilitate efficient viral replication and transmission. In this study, we found that the filovirus glycoprotein (GP) expressed on cell surfaces formed a steric shield over the Fas molecule and that GP-expressing cells showed resistance to cell death induced by a Fas agonistic antibody. These results suggest that filovirus GP-mediated steric shielding may interfere with the Fas-induced apoptotic signal transduction in infected cells and serve as an immune evasion mechanism for filoviruses. (C) 2013 Elsevier Inc. All rights reserved.
Type: article (author version)
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高田 礼人

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