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Hokkaido University Collection of Scholarly and Academic Papers >
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Diffuse infiltrating retinoblastoma invading subarachnoid space
| Title: | Diffuse infiltrating retinoblastoma invading subarachnoid space |
| Authors: | Kase, Satoru Browse this author →KAKEN DB | | Yoshida, Kazuhiko Browse this author →KAKEN DB | | Suzuki, Shigenobu Browse this author | | Ohno, Shigeaki Browse this author →KAKEN DB | | Ishida, Susumu Browse this author →KAKEN DB |
| Keywords: | diffuse infiltrating retinoblastoma | | subarachnoid space | | optic nerve |
| Issue Date: | 23-Jun-2011 |
| Publisher: | Dove Medical Press |
| Journal Title: | Clinical Ophthalmology |
| Volume: | 5 |
| Start Page: | 861 |
| End Page: | 863 |
| Publisher DOI: | 10.2147/OPTH.S20913 |
| PMID: | 21760712 |
| Abstract: | We report herein an unusual case of diffuse infiltrating retinoblastoma involving the brain, which caused a patient’s death 27 months after enucleation. An eight-year-old boy complained of blurred vision in his right eye (OD) in October 2006. Funduscopic examination showed optic disc swelling, dense whitish vitreous opacity, and an orange-colored subretinal elevated lesion adjacent to the optic disc. Fluorescein angiography revealed hyperfluorescence in the peripapillary region at an early-phase OD. Because the size of the subretinal lesion and vitreous opacity gradually increased, he was referred to us. His visual acuity was 20/1000 OD on June 20, 2007. Slit-lamp biomicroscopy showed a dense anterior vitreous opacity. Ophthalmoscopically, the subretinal orange-colored area spread out until reaching the mid peripheral region. A B-mode sonogram and computed tomography showed a thick homogeneous lesion without calcification. Gadolinium-enhanced magnetic resonance imaging showed a markedly enhanced appearance of the underlying posterior retina. Enucleation of the right eye was performed nine months after the initial presentation. Histopathology demonstrated retinal detachment and a huge choroidal mass invading the optic nerve head. The tumor was consistent with diffuse infiltrating retinoblastoma. The patient died due to brain involvement 27 months after enucleation. Ophthalmologists should be aware that diffuse infiltrating retinoblastoma may show an unfavorable course if its diagnosis is delayed. |
| Relation: | http://www.dovepress.com/diffuse-infiltrating-retinoblastoma-invading-subarachnoid-space-peer-reviewed-article-OPTH |
| Type: | article |
| URI: | http://hdl.handle.net/2115/54621 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 石田 晋
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