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Diffuse infiltrating retinoblastoma invading subarachnoid space

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/54621

Title: Diffuse infiltrating retinoblastoma invading subarachnoid space
Authors: Kase, Satoru Browse this author →KAKEN DB
Yoshida, Kazuhiko Browse this author →KAKEN DB
Suzuki, Shigenobu Browse this author
Ohno, Shigeaki Browse this author →KAKEN DB
Ishida, Susumu Browse this author →KAKEN DB
Keywords: diffuse infiltrating retinoblastoma
subarachnoid space
optic nerve
Issue Date: 23-Jun-2011
Publisher: Dove Medical Press
Journal Title: Clinical Ophthalmology
Volume: 5
Start Page: 861
End Page: 863
Publisher DOI: 10.2147/OPTH.S20913
PMID: 21760712
Abstract: We report herein an unusual case of diffuse infiltrating retinoblastoma involving the brain, which caused a patient’s death 27 months after enucleation. An eight-year-old boy complained of blurred vision in his right eye (OD) in October 2006. Funduscopic examination showed optic disc swelling, dense whitish vitreous opacity, and an orange-colored subretinal elevated lesion adjacent to the optic disc. Fluorescein angiography revealed hyperfluorescence in the peripapillary region at an early-phase OD. Because the size of the subretinal lesion and vitreous opacity gradually increased, he was referred to us. His visual acuity was 20/1000 OD on June 20, 2007. Slit-lamp biomicroscopy showed a dense anterior vitreous opacity. Ophthalmoscopically, the subretinal orange-colored area spread out until reaching the mid peripheral region. A B-mode sonogram and computed tomography showed a thick homogeneous lesion without calcification. Gadolinium-enhanced magnetic resonance imaging showed a markedly enhanced appearance of the underlying posterior retina. Enucleation of the right eye was performed nine months after the initial presentation. Histopathology demonstrated retinal detachment and a huge choroidal mass invading the optic nerve head. The tumor was consistent with diffuse infiltrating retinoblastoma. The patient died due to brain involvement 27 months after enucleation. Ophthalmologists should be aware that diffuse infiltrating retinoblastoma may show an unfavorable course if its diagnosis is delayed.
Relation: http://www.dovepress.com/diffuse-infiltrating-retinoblastoma-invading-subarachnoid-space-peer-reviewed-article-OPTH
Type: article
URI: http://hdl.handle.net/2115/54621
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石田 晋

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