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Possible implication of disordered neutrophil extracellular traps in the pathogenesis of MPO-ANCA-associated vasculitis

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この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/54623

タイトル: Possible implication of disordered neutrophil extracellular traps in the pathogenesis of MPO-ANCA-associated vasculitis
著者: Nakazawa, Daigo 著作を一覧する
Tomaru, Utano 著作を一覧する
Ishizu, Akihiro 著作を一覧する
キーワード: NETs
PTU
MPO-ANCA
MPO-AAV
発行日: 2013年10月
出版者: Springer
誌名: Clinical and Experimental Nephrology
巻: 17
号: 5
開始ページ: 631
終了ページ: 633
出版社 DOI: 10.1007/s10157-012-0738-8
抄録: Neutrophil extracellular traps (NETs) are characterized by the presence of extracellular DNA fibers studded with antimicrobial proteins, including myeloperoxidase (MPO). Although NETs play an important role in the innate immune system, the scattered extracellular enzymes, such as MPO, pose risks to the host. Therefore, NETs are strictly regulated by DNase I in the serum, which prevents them from persisting. Recent studies have demonstrated that dysregulation of NETs could be involved in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus. In this review, we interpret the association of disordered NETs with autoimmune diseases, especially propylthiouracil-induced MPO-ANCA-associated vasculitis.
Rights: The final publication is available at www.springerlink.com
Relation (URI): http://link.springer.com/article/10.1007%2Fs10157-012-0738-8
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/54623
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 石津 明洋

 

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