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Abundant neutrophil extracellular traps in thrombus of patient with microscopic polyangiitis

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Title: Abundant neutrophil extracellular traps in thrombus of patient with microscopic polyangiitis
Authors: Nakazawa, Daigo Browse this author
Tomaru, Utano Browse this author →KAKEN DB
Yamamoto, Chiho Browse this author
Jodo, Satoshi Browse this author
Ishizu, Akihiro Browse this author →KAKEN DB
Keywords: MPO-ANCA
deep vein thrombosis
histone-citrullination
microscopic polyangiitis
neutrophil extracellular traps
Issue Date: Nov-2012
Journal Title: Frontiers in Immunology
Volume: 3
Publisher DOI: 10.3389/fimmu.2012.00333
Abstract: This is a case study of a patient diagnosed with microscopic polyangiitis (MPA) and complicated with deep vein thrombosis (DVT), who died of respiratory failure despite treatment. Autopsy revealed severe crescentic glomerulonephritis and massive alveolar hemorrhage. The thrombus contained abundant neutrophils. Although it is reported that patients with ANCA-associated vasculitis (AAV) have an increased risk of DVT, it remains elusive why they are prone to thrombosis. A recent study has demonstrated the presence of neutrophil extracellular traps (NETs), a newly recognized mode of neutrophil cell-death, in glomerular crescents of MPA patients. Interestingly, NETs were identified in the thrombus as well as in the glomerular crescents in the present case. When compared to other thrombi unrelated to MPA, the amount of NETs was significantly greater in the MPA patient. On the other hand, NETs are critically involved in thrombogenesis because histones within NETs can bind platelets and blood coagulants. Although this is important in regard to containment of microbes within NETs, excessive NETs could cause thrombosis. The collective findings suggest the possibility that thrombosis could be critically associated with MPA via NETs, and that NETs could be a therapeutic target in MPA patients.
Rights: http://creativecommons.org/licenses/by-nc-sa/2.1/jp/
Type: article
URI: http://hdl.handle.net/2115/54630
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石津 明洋

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