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Evaluation of inter-observer variability of bladder boundary delineation on cone-beam CT

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Title: Evaluation of inter-observer variability of bladder boundary delineation on cone-beam CT
Authors: Nishioka, Kentaro Browse this author →KAKEN DB
Shimizu, Shinichi Browse this author →KAKEN DB
Kinoshita, Rumiko Browse this author →KAKEN DB
Inoue, Tetsuya Browse this author →KAKEN DB
Onodera, Shunsuke Browse this author
Yasuda, Koichi Browse this author →KAKEN DB
Harada, Keiichi Browse this author
Nishikawa, Yukiko Browse this author
Onimaru, Rikiya Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Keywords: Bladder cancer
Image guided radiotherapy
Cone beam CT
Inter-observer variability
Issue Date: 23-Jul-2013
Publisher: BioMed Central Ltd
Journal Title: Radiation Oncology
Volume: 8
Issue: 1
Start Page: 185
Publisher DOI: 10.1186/1748-717X-8-185
PMID: 23879876
Abstract: Background: In-room cone-beam computerized tomography (CBCT) imaging is a promising method to reduce setup errors, especially in organs such as the bladder that often have large intrafractional variations due to organ movement. CBCT image quality is limited by low contrast and imaging artifacts, but few data have been reported about inter-observer variability of bladder boundary delineation on CBCT. The aim of this work was to analyze and evaluate the inter-observer contouring uncertainties of bladder boundary delineation on CBCT images in a prospective fashion. Methods: Five radiation oncologists contoured 10 bladders using the CBCT datasets of consecutive 10 patients (including 4 females) who were irradiated to the pelvic region. Prostates were also contoured in male patients. Patients who had had prostatectomy were excluded. The coefficient of variation (COV), conformity index (CIgen), and coordinates of center-of-mass (COM) of the bladder and prostate were calculated for each patient. Results: The mean COV for the bladder and prostate was 0.08 and 0.20, respectively. The mean CIgen of the bladder and prostate was 0.81 and 0.66, respectively. The root mean square (RMS) of the inter-observer standard deviation (σ) of the COM displacement in the left-right (LR) and anterior-posterior (AP) direction was 0.79, 0.87 and 0.54 for the bladder and 0.63, 0.99 and 1.72 for the prostate. Regarding the mean COV and CIgen for the bladder, the differences between males and females were not significant. Conclusions: Inter-observer variability for bladder delineation on CBCT images was substantially small regardless of gender. We believe that our results support the applicability of CBCT in adaptive radiotherapy for bladder cancer.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 西岡 健太郎

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