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Essential thrombocythemia as a risk factor for stillbirth

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Title: Essential thrombocythemia as a risk factor for stillbirth
Authors: Umazume, Takeshi Browse this author →KAKEN DB
Yamada, Takahiro Browse this author →KAKEN DB
Akaishi, Rina Browse this author
Araki, Naoto Browse this author
Nishida, Ryutaro Browse this author
Morikawa, Mamoru Browse this author →KAKEN DB
Minakami, Hisanori Browse this author →KAKEN DB
Keywords: Deep vein thrombosis
Essential thrombocythemia
Low-dose aspirin
Placental abruption
Issue Date: Feb-2014
Publisher: Pergamon-elsevier science ltd
Journal Title: Thrombosis research
Volume: 133
Issue: 2
Start Page: 158
End Page: 161
Publisher DOI: 10.1016/j.thromres.2013.11.004
PMID: 24268792
Abstract: Introduction: The risk of abortion is known to be high in women with essential thrombocythemia (ET). However, a few studies have focused on the risk of stillbirth among fetuses reaching gestational age compatible with life. Methods: Review of medical charts of pregnant women with ET who received cares at a single center between January 2003 and June 2013 and the English literature in which more than 20 pregnancies with ET were dealt with regarding outcomes. Outcomes were classified into three categories: spontaneous abortion or preterm delivery before GW 24, stillbirth at and after GW 24, and live birth (LB). Japan national statistics was used to estimate the risk of stillbirth among women with GW 22 or more. Results: In all nine pregnancies in four women with ET at our hospital, two miscarriages, one stillbirth (intrauterine death at GW 35), and six LBs occurred. There were six reports in the English literature in which a total of 374 pregnancy outcomes were described: 110 miscarriages (29%), 14 stillbirths (3.7% of all 374 pregnancies and 5.3% of 264 pregnancies with GW >= 24), and 250 LBs (67%) occurred. Japan national statistics between 1995 and 2011 indicated that the risk of stillbirth was less than 0.50% among women with GW >= 22. Conclusions: The risk of still birth was extremely high among women with ET. More intensified monitoring of fetal wellbeing may be required to improve outcome of pregnancy complicated with ET. (C) 2013 Elsevier Ltd. All rights reserved.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山田 崇弘

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