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Hydroxylamine enhances glucose uptake in C2C12 skeletal muscle cells through the activation of insulin receptor substrate 1

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Title: Hydroxylamine enhances glucose uptake in C2C12 skeletal muscle cells through the activation of insulin receptor substrate 1
Authors: Kimura, Taro Browse this author
Kato, Eisuke Browse this author →KAKEN DB
Machikawa, Tsukasa Browse this author
Kimura, Shunsuke Browse this author →KAKEN DB
Katayama, Shinji Browse this author
Kawabata, Jun Browse this author →KAKEN DB
Keywords: Diabetes mellitus
Insulin
Glucose uptake
Hydroxylamine
PI3 K/Akt signaling
Skeletal muscle
Issue Date: Feb-2014
Publisher: Elsevier
Journal Title: Biochemical and Biophysical Research Communications
Volume: 445
Issue: 1
Start Page: 6
End Page: 9
Publisher DOI: 10.1016/j.bbrc.2014.01.039
PMID: 24462868
Abstract: Diabetes mellitus is a global disease, and the number of patients with it is increasing. Of various agents for treatment, those that directly act on muscle are currently attracting attention because muscle is one of the main tissues in the human body, and its metabolism is decreased in type II diabetes. In this study, we found that hydroxylamine (HA) enhances glucose uptake in C2C12 myotubes. Analysis of HA’s mechanism revealed the involvement of IRS1, PI3 K and Akt that is related to the insulin signaling pathway. Further investigation about the activation mechanism of insulin receptor or IRS1 by HA may provide a way to develop a novel anti-diabetic agent alternating to insulin.
Type: article (author version)
URI: http://hdl.handle.net/2115/54788
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 英介

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