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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
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Hydroxylamine enhances glucose uptake in C2C12 skeletal muscle cells through the activation of insulin receptor substrate 1
| Title: | Hydroxylamine enhances glucose uptake in C2C12 skeletal muscle cells through the activation of insulin receptor substrate 1 |
| Authors: | Kimura, Taro Browse this author | | Kato, Eisuke Browse this author →KAKEN DB | | Machikawa, Tsukasa Browse this author | | Kimura, Shunsuke Browse this author →KAKEN DB | | Katayama, Shinji Browse this author | | Kawabata, Jun Browse this author →KAKEN DB |
| Keywords: | Diabetes mellitus | | Insulin | | Glucose uptake | | Hydroxylamine | | PI3 K/Akt signaling | | Skeletal muscle |
| Issue Date: | Feb-2014 |
| Publisher: | Elsevier |
| Journal Title: | Biochemical and Biophysical Research Communications |
| Volume: | 445 |
| Issue: | 1 |
| Start Page: | 6 |
| End Page: | 9 |
| Publisher DOI: | 10.1016/j.bbrc.2014.01.039 |
| PMID: | 24462868 |
| Abstract: | Diabetes mellitus is a global disease, and the number of patients with it is increasing. Of various agents for treatment, those that directly act on muscle are currently attracting attention because muscle is one of the main tissues in the human body, and its metabolism is decreased in type II diabetes. In this study, we found that hydroxylamine (HA) enhances glucose uptake in C2C12 myotubes. Analysis of HA’s mechanism revealed the involvement of IRS1, PI3 K and Akt that is related to the insulin signaling pathway. Further investigation about the activation mechanism of insulin receptor or IRS1 by HA may provide a way to develop a novel anti-diabetic agent alternating to insulin. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/54788 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 加藤 英介
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